C1q

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Specie Reactivity Human
Sensitivity 0.121 ng/mL (70.312-20 ng/mL)
Applications ELISA
Specie Reactivity Human
Sensitivity 0.61 ng/mL (1.56-100 ng/mL)
Applications ELISA
Specie Reactivity Mouse
Sensitivity 0.244 ng/mL (0.625-40 ng/mL)
Applications ELISA
Specie Reactivity Mouse
Sensitivity 13.1 ng/mL (31.2-2000 ng/mL)
Applications ELISA
Specie Reactivity Rat
Sensitivity 0.63 ng/mL (1.56-100 ng/mL)
Applications ELISA
Specie Reactivity Rat
Sensitivity 0.017 ng/mL (0.05-50n g/mL)
Applications ELISA
Specie Reactivity Rabbit
Sensitivity 1.875 pg/mL (3.125-200 pg/mL)
Applications ELISA
Specie Reactivity Chicken
Sensitivity 2.344 pg/mL (3.906-250 pg/mL)
Applications ELISA
Specie Reactivity Ovine
Sensitivity 23.438 pg/mL (39.063-2500 pg/mL)
Applications ELISA
Specie Reactivity Porcine
Sensitivity 46.875 pg/mL (78.125-5000 pg/mL)
Applications ELISA
Specie Reactivity Guinea Porcine
Sensitivity 2.344 pg/mL (3.906-250 pg/mL)
Applications ELISA
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Host Animal Rabbit
Specie Reactivity Human
Isotype IgG
Applications WB; IHC
Host Animal Sheep
Specie Reactivity Human
Isotype IgG
Applications ELISA; FC; ID
Host Animal Mouse
Specie Reactivity Human
Antibody Clone CTJS-734
Isotype IgG1
Applications WB; ELISA
Host Animal Goats
Isotype IgG
Applications Western Blots; ELISA; Immunodiffusion
Host Animal Goats
Isotype IgG
Applications Immunodiffusion
Host Animal Mouse
Specie Reactivity Human
Antibody Clone TJL-03
Isotype IgG1 Kappa
Applications IP; ELISA
Host Animal Mouse
Specie Reactivity Human
Antibody Clone TJL-03
Isotype IgG1 Kappa
Applications IP
Host Animal Mouse
Specie Reactivity Human
Antibody Clone TJL-03
Isotype IgG1 Kappa
Applications WB; IHC; ELISA
Host Animal Mouse
Specie Reactivity Human
Antibody Clone TJL-03
Isotype IgG1 Kappa
Applications IF; IHC; FCM
Host Animal Mouse
Specie Reactivity Human
Antibody Clone TJL-03
Isotype IgG1 Kappa
Applications IF; IHC; FCM
Host Animal Mouse
Specie Reactivity Human
Antibody Clone TJL-03
Isotype IgG1 Kappa
Applications WB; IF; IHC; FCM
Host Animal Mouse
Specie Reactivity Human
Antibody Clone TJL-03
Isotype IgG1 Kappa
Applications WB; IF; IHC; FCM
Host Animal Mouse
Specie Reactivity Human
Antibody Clone TJL-03
Isotype IgG1 Kappa
Applications WB; IF; IHC; FCM
Host Animal Mouse
Specie Reactivity Human
Antibody Clone TJL-03
Isotype IgG1 Kappa
Applications WB; IF; IHC(P); FCM
Host Animal Mouse
Specie Reactivity Human
Antibody Clone TJL-03
Isotype IgG1 Kappa
Applications WB; IF; FCM
Host Animal Mouse
Specie Reactivity Human
Antibody Clone TJL-03
Isotype IgG1 Kappa
Applications WB; IF; FCM
Host Animal Mouse
Specie Reactivity Mouse
Antibody Clone TJL-04
Isotype IgG2b
Applications WB; IHC(F); ELISA; FN
Host Animal Mouse
Specie Reactivity Mouse
Antibody Clone TJL-04
Isotype IgG2b
Applications WB; IHC(F); ELISA; FN
Host Animal Mouse
Specie Reactivity Mouse
Antibody Clone TJL-04
Isotype IgG2b
Applications WB; IHC(F); ELISA (ELISA); FN
Host Animal Rat
Specie Reactivity Mouse
Antibody Clone TJL-05
Isotype IgG1
Applications IHC; ELISA
Host Animal Mouse
Specie Reactivity Human
Antibody Clone TJL-06
Isotype IgG1
Applications WB
Host Animal Mouse
Specie Reactivity Human
Antibody Clone TJL-07
Isotype IgG1
Applications WB; IHC(F); Flow; ELISA
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Specie Reactivity Human
Type Recombinant Protein Antigen
Expression Host E. Coli
Applications AC
Specie Reactivity Human
Type Native Protein
Applications ELISA; Functional Assays
Specie Reactivity Cynomolgus Monkey
Type Native Protein
Applications ELISA
Specie Reactivity Mouse
Type Native Protein
Applications ELISA
Specie Reactivity Rat
Type Native Protein
Applications ELISA
[Cat#: CTMM-2410-JL7] Native Rabbit Complement C1q Protein
Type Native Protein
Expression Host Normal rabbit serum
Applications Functional Assays
Solubility Soluble in water
Product Overview Complement C1 Peptide Inhibitor-PIC1 is a highly potent C1 inhibitor which can inhibit ~90% complement activity in a hemolytic assay at Conc. 0.77mM. This inhibitor specifically inhibits the classical and lectin pathways of complement by binding to C1q, it also can bound to the lectin pathway initiator molecule MBL as well as the ficolins H, M and L.
Product List Background

Background

Complement C1q, a 460 kDa hexameric glycoprotein, is the first recognition subcomponent of the complement classical pathway. This protein is made up of 18 polypeptide chains, consisting of 9 non-covalently linked subunits having 6 of A, B, and C chains (Fig.1). These chains contain three different domains which are a short N-terminal region (3-9 residues), a collagen region having 81 residues, and a C-terminal globular (gC1q) domain of about 185 residues. C1q is able to bind many antibodies and ligands, including IgG, IgM, CRP, phosphatidylserine (PS), HIV-1, HTLV-1, as well as some receptors such as integrin α2β1 and calreticulin-CD91.

C1q has a variety of complement and non-complement functions. Firstly, C1q can bind a range of ligands derived from self, non-self, and altered self and modulate the functions of immune and non-immune cells including dendritic cells and microglia. Moreover, C1q is associated with the clearance of apoptotic cells and subsequent B cell tolerance. Previous research has demonstrated that C1q plays a crucial role in pregnancy where its deficiency and dysregulation can have adverse effects, resulting in missed abortion, preeclampsia, or spontaneous loss, and infections. In addition, C1q is generated in the central nervous system and has a protective role against pathogens and possible inflammatory functions while interacting with aggregated proteins leading to neurodegenerative diseases.

Structure of C1q.Fig.1 Structure of C1q.1, 2

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References

  1. Kouser, Lubna, et al. "Emerging and novel functions of complement protein C1q." Frontiers in immunology 6 (2015): 317.
  2. under Open Access license CC BY 4.0, without modification
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For Research Use Only.