C1R

Clear All
Host Animal Mouse
Specie Reactivity Human
Antibody Clone CTJS-356
Isotype IgG2b
Applications WB; IP
Host Animal Mouse
Specie Reactivity Human
Antibody Clone CTJS-79
Isotype IgG2b
Applications WB
Host Animal Goat
Specie Reactivity Human
Isotype IgG
Applications WB; IP; ELISA
Host Animal Rabbit
Specie Reactivity Human
Isotype IgG
Applications WB; IHC
Host Animal Mouse
Specie Reactivity Human; Dog
Antibody Clone CTJS-26
Isotype IgG2b
Applications WB; IHC
Host Animal Mouse
Specie Reactivity Human; Mouse; Rat
Antibody Clone CTJS-59
Isotype IgG1 κ
Applications WB; IP; IF; ELISA
Host Animal Mouse
Specie Reactivity Human; Mouse; Rat
Antibody Clone CTJS-663
Isotype IgG2b κ
Applications WB; IP; IF; ELISA
Host Animal Mouse
Specie Reactivity Human; Mouse; Rat
Antibody Clone CTJS-663
Isotype IgG2b κ
Applications IP
Host Animal Mouse
Specie Reactivity Human; Mouse; Rat
Antibody Clone CTJS-663
Isotype IgG2b κ
Applications WB; IHC; ELISA
Host Animal Mouse
Specie Reactivity Human; Mouse; Rat
Antibody Clone CTJS-663
Isotype IgG2b κ
Applications IF; IHC; FC
Host Animal Mouse
Specie Reactivity Human; Mouse; Rat
Antibody Clone CTJS-663
Isotype IgG2b κ
Applications IF; IHC; FC
Host Animal Mouse
Specie Reactivity Human; Mouse; Rat
Antibody Clone CTJS-663
Isotype IgG2b κ
Applications WB; IF; IHC; FC
Host Animal Mouse
Specie Reactivity Human; Mouse; Rat
Antibody Clone CTJS-663
Isotype IgG2b κ
Applications WB; IF; IHC; FC
Host Animal Mouse
Specie Reactivity Human; Mouse; Rat
Antibody Clone CTJS-663
Isotype IgG2b κ
Applications WB; IF; IHC; FC
Host Animal Mouse
Specie Reactivity Human; Mouse; Rat
Antibody Clone CTJS-663
Isotype IgG2b κ
Applications WB; IF; IHC; FC
Host Animal Mouse
Specie Reactivity Human; Mouse; Rat
Antibody Clone CTJS-663
Isotype IgG2b κ
Applications WB; IF; FC
Host Animal Mouse
Specie Reactivity Human; Mouse; Rat
Antibody Clone CTJS-663
Isotype IgG2b κ
Applications WB; IF; FC
Host Animal Goats
Isotype IgG
Applications Immunodiffusion
Host Animal Mouse
Specie Reactivity Human
Antibody Clone TJL-01
Isotype IgG2b
Applications WB; IP; IF; IHC; FCM
Host Animal Mouse
Specie Reactivity Human
Antibody Clone TJL-01
Isotype IgG2b
Applications IP
Host Animal Mouse
Specie Reactivity Human
Antibody Clone TJL-01
Isotype IgG2b
Applications WB; IHC; ELISA
Host Animal Mouse
Specie Reactivity Human
Antibody Clone TJL-01
Isotype IgG2b
Applications IF; IHC; FCM
Host Animal Mouse
Specie Reactivity Human
Antibody Clone TJL-01
Isotype IgG2b
Applications IF; IHC; FCM
Host Animal Mouse
Specie Reactivity Human
Antibody Clone TJL-01
Isotype IgG2b
Applications WB; IF; IHC; FCM
Host Animal Mouse
Specie Reactivity Human
Antibody Clone TJL-01
Isotype IgG2b
Applications WB; IF; IHC; FCM
Host Animal Mouse
Specie Reactivity Human
Antibody Clone TJL-01
Isotype IgG2b
Applications WB; IF; IHC; FCM
Host Animal Mouse
Specie Reactivity Human
Antibody Clone TJL-01
Isotype IgG2b
Applications WB; IF; IHC; FCM
Host Animal Mouse
Specie Reactivity Human
Antibody Clone TJL-01
Isotype IgG2b
Applications WB; IF; FCM
Host Animal Mouse
Specie Reactivity Human
Antibody Clone TJL-01
Isotype IgG2b
Applications WB; IF; FCM
Host Animal Mouse
Specie Reactivity Human
Antibody Clone TJL-02
Isotype IgG1
Applications WB; IP; IF; ELISA
Clear All
Specie Reactivity Human
Sensitivity 0.073 ng/mL (0.156-10 ng/mL)
Applications ELISA
Specie Reactivity Human
Sensitivity 0.144 ng/mL (0.312-20 ng/mL)
Applications ELISA
Specie Reactivity Human
Sensitivity 2.71 pg/mL (6.86-5000 pg/mL)
Applications ELISA
Specie Reactivity Mouse
Sensitivity 15.6 ng/mL (62.5-4000 ng/mL)
Applications ELISA
Specie Reactivity Mouse
Sensitivity 0.1 ng/mL (2.5-50 ng/mL)
Applications ELISA
Specie Reactivity Rat
Sensitivity 0.94 ng/mL (1.56-100 ng/mL)
Applications ELISA
Specie Reactivity Rabbit
Sensitivity 75 pg/mL (125-8000 pg/mL)
Applications ELISA
Specie Reactivity Rabbit
Sensitivity 0.1 ng/mL (2.5-50 ng/mL)
Applications ELISA
Specie Reactivity Chicken
Sensitivity 0.188 ng/mL (0.313-20 ng/mL)
Applications ELISA
Specie Reactivity Porcine
Sensitivity 0.188 ng/mL (0.313-20 ng/mL)
Applications ELISA
Specie Reactivity Guinea Porcine
Sensitivity 18.75 pg/mL (31.25-2000 pg/mL)
Applications ELISA
Specie Reactivity Guinea Porcine
Sensitivity 0.1 ng/mL (2.5-50 ng/mL)
Applications ELISA
Specie Reactivity Monkey
Sensitivity 0.188 ng/mL (0.313-20 ng/mL)
Applications ELISA
Specie Reactivity Monkey
Sensitivity 0.1 ng/mL (2.5-50 ng/mL)
Applications ELISA
Specie Reactivity Canine
Sensitivity 0.1 ng/mL (2.5-50 ng/mL)
Applications ELISA
Specie Reactivity Human
Type Recombinant Protein Antigen
Expression Host E. Coli
Applications AC
Specie Reactivity Human
Type Recombinant Protein Antigen
Expression Host E. Coli
Applications AC
Specie Reactivity Human
Type Recombinant Protein
Expression Host Mouse myeloma cell line, NS0
Applications Enzyme Activity Assays
Specie Reactivity Human
Type Recombinant Protein
Expression Host Yeast
Applications WB; ELISA
Specie Reactivity Human
Type Recombinant Protein
Expression Host E.coli/Mammalian cell/Baculovirus
Applications WB; ELISA
Specie Reactivity Human
Purity >90%
Applications Blocking; WB
Specie Reactivity Human
Purity >90%
Applications Blocking; WB
Specie Reactivity Human
Purity >90%
Applications Blocking
Specie Reactivity Human; Monkey; Mouse; Rat
Purity >90%
Applications Immunogen
Specie Reactivity Human; Mouse
Purity >85%
Applications Immunogen
Specie Reactivity Human
Species of Lysate 293T Cells
Application Western Blotting (WB)
Clear All
Specie Reactivity Human
Type Expression Plasmid
Vector pCMV6-Entry
Tag Myc-DDK
Specie Reactivity Human
Type Expression Plasmid
Vector pCMV6-AC-GFP
Tag GFP
Specie Reactivity Human
Type Expression Plasmid
Vector pLenti-C-Myc-DDK
Tag Myc-DDK
Specie Reactivity Human
Type Expression Plasmid
Vector pLenti-C-mGFP
Tag mGFP
Specie Reactivity Human
Type Expression Plasmid
Vector pLenti-C-Myc-DDK-P2A-Puro
Tag Myc-DDK
Specie Reactivity Human
Type Expression Plasmid
Vector pLenti-C-mGFP-P2A-Puro
Tag mGFP
Specie Reactivity Human
Type Expression Plasmid
Vector pCMV6-XL5
Specie Reactivity Rat
Type Expression Plasmid
Vector pCMV6-Entry
Tag Myc-DDK
Specie Reactivity Rat
Type Expression Plasmid
Vector pLenti-C-Myc-DDK-P2A-Puro
Tag Myc-DDK
Specie Reactivity Rat
Type Expression Plasmid
Vector pLenti-C-mGFP-P2A-Puro
Tag mGFP
Specie Reactivity Rat
Type Expression Plasmid
Vector pCMV6-Entry
Specie Reactivity Mouse
Type Expression Plasmid
Vector pCMV6-Entry
Tag Myc-DDK
Specie Reactivity Mouse
Type Expression Plasmid
Vector pCMV6-AC-GFP
Tag GFP
Specie Reactivity Mouse
Type Expression Plasmid
Vector pCMV6-AC-GFP
Tag GFP
Specie Reactivity Mouse
Type Expression Plasmid
Vector pLenti-C-Myc-DDK-P2A-Puro
Tag Myc-DDK
Specie Reactivity Mouse
Type Expression Plasmid
Vector pLenti-C-mGFP-P2A-Puro
Tag mGFP
Product List Background

Background

Complement C1r, a modular serine protease in the serum C1 complex, forms a homodimer of 173 kDa. It has two N-terminal CUB domains, separated by an epidermal growth factor (EGF)-like domain, followed by two complement control modules (CCPs) and a C-terminal serine protease (SP) domain. C1r is mainly related to the homologous C1s protease in a calcium-dependent manner. Moreover, the expression of the C1r and C1s proteases is coordinated in hepatocytes. The main function of them is the activation of the classical complement pathway. When the C1 complex binds to an activating target, the C1r is activated, which is induced by the cleavage of a single Arg-Ile bond, which triggers a conformational transition towards the active state.

Until now, structures of the C1r catalytic domain have been determined in both the proenzyme and activated states. To date, C1r complete deficiencies are rare and often associated with pyogenic infections and autoimmune diseases such as systemic lupus erythematosus. Some heterozygous C1r mutations are associated with periodontal Ehlers-Danlos syndrome. Besides, scientists have demonstrated that enhanced expression of C1 complex proteases is related to increased tissue inflammation and complement C3 formation and represents an important pathogenic mechanism leading to FA-mediated tubulointerstitial fibrosis.

Fig. 1 C1r function. (Zhang et al., 2023)

References

  1. Zhang, Wenjie, Yuan Chen, and Hui Pei. "C1q and central nervous system disorders." Frontiers in Immunology 14 (2023): 1145649.
  2. under Open Access license CC BY 4.0, without modification
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For Research Use Only.