C1S

Clear All
Host Animal Mouse
Specie Reactivity Human; Monkey
Antibody Clone CTJS-457
Isotype IgG2a
Applications WB; FC; IF; IHC
Host Animal Mouse
Specie Reactivity Human
Antibody Clone CTJS-171
Isotype IgG2a
Applications WB; IHC
Host Animal Mouse
Specie Reactivity Human
Antibody Clone CTJS-627
Isotype IgG2a
Applications WB; FC; IA; IHC; Neut
Host Animal Mouse
Specie Reactivity Human
Antibody Clone CTJS-146
Isotype IgG1
Applications WB; IP
Host Animal Mouse
Specie Reactivity Human
Antibody Clone CTJS-459
Isotype IgG1κ
Applications ELISA
Host Animal Mouse
Specie Reactivity Human
Antibody Clone CTJS-395
Isotype IgG1κ
Applications ELISA; IHC
Host Animal Rabbit
Specie Reactivity Human
Isotype IgG
Applications WB; IHC
Host Animal Goat
Specie Reactivity Human
Isotype IgG
Applications ELISA; IHC
Host Animal Sheep
Specie Reactivity Human
Isotype IgG
Applications WB; ELISA
Host Animal Mouse
Specie Reactivity Human
Antibody Clone CTJS-304
Isotype IgG2a
Applications WB; IHC; FC
Host Animal Mouse
Specie Reactivity Human
Antibody Clone CTJS-539
Isotype IgG2b κ
Applications WB; IP; IF; ELISA
Host Animal Mouse
Specie Reactivity Human
Antibody Clone CTJS-539
Isotype IgG2b κ
Applications IP
Host Animal Mouse
Specie Reactivity Human
Antibody Clone CTJS-539
Isotype IgG2b κ
Applications WB; IHC; ELISA
Host Animal Mouse
Specie Reactivity Human
Antibody Clone CTJS-539
Isotype IgG2b κ
Applications IF; IHC; FC
Host Animal Mouse
Specie Reactivity Human
Antibody Clone CTJS-539
Isotype IgG2b κ
Applications IF; IHC; FC
Host Animal Mouse
Specie Reactivity Human
Antibody Clone CTJS-539
Isotype IgG2b κ
Applications WB; IF; IHC; FC
Host Animal Mouse
Specie Reactivity Human
Antibody Clone CTJS-539
Isotype IgG2b κ
Applications WB; IF; IHC; FC
Host Animal Mouse
Specie Reactivity Human
Antibody Clone CTJS-539
Isotype IgG2b κ
Applications WB; IF; IHC; FC
Host Animal Mouse
Specie Reactivity Human
Antibody Clone CTJS-539
Isotype IgG2b κ
Applications WB; IF; IHC; FC
Host Animal Mouse
Specie Reactivity Human
Antibody Clone CTJS-539
Isotype IgG2b κ
Applications WB; IF; FC
Host Animal Mouse
Specie Reactivity Human
Antibody Clone CTJS-539
Isotype IgG2b κ
Applications WB; IF; FC
Host Animal Mouse
Specie Reactivity Human
Antibody Clone CTJS-539
Isotype IgG2b κ
Applications WB; IHC; ELISA
Host Animal Goats
Isotype IgG
Applications Immunodiffusion
Host Animal Mouse
Specie Reactivity Human
Antibody Clone TJL-14
Isotype IgG1
Applications WB; IP
Host Animal Rabbit Monoclonal
Specie Reactivity Human
Antibody Clone TJL-15
Isotype IgG
Applications ELISA
Host Animal Mouse
Specie Reactivity Human
Antibody Clone TJL-16
Isotype IgG1
Applications WB; IA
Host Animal Mouse
Specie Reactivity Human
Antibody Clone TJL-17
Isotype IgG1
Applications WB; IA
Host Animal Mouse
Specie Reactivity Human
Antibody Clone TJL-18
Isotype IgG2b Kappa
Applications WB; IP; IF; IHC; ELISA
Host Animal Mouse
Specie Reactivity Human
Antibody Clone TJL-18
Isotype IgG2b Kappa
Applications IP
Host Animal Mouse
Specie Reactivity Human
Antibody Clone TJL-18
Isotype IgG2b Kappa
Applications WB; IHC; ELISA
Host Animal Mouse
Specie Reactivity Human
Antibody Clone TJL-18
Isotype IgG2b Kappa
Applications IF; IHC; FCM
Host Animal Mouse
Specie Reactivity Human
Antibody Clone TJL-18
Isotype IgG2b Kappa
Applications IF; IHC; FCM
Host Animal Mouse
Specie Reactivity Human
Antibody Clone TJL-18
Isotype IgG2b Kappa
Applications WB; IF; IHC; FCM
Host Animal Mouse
Specie Reactivity Human
Antibody Clone TJL-18
Isotype IgG2b Kappa
Applications WB; IF; IHC; FCM
Host Animal Mouse
Specie Reactivity Human
Antibody Clone TJL-18
Isotype IgG2b Kappa
Applications WB; IF; IHC; FCM
Host Animal Mouse
Specie Reactivity Human
Antibody Clone TJL-18
Isotype IgG2b Kappa
Applications WB; IF; IHC; FCM
Host Animal Mouse
Specie Reactivity Human
Antibody Clone TJL-18
Isotype IgG2b Kappa
Applications WB; IF; FCM
Host Animal Mouse
Specie Reactivity Human
Antibody Clone TJL-18
Isotype IgG2b Kappa
Applications WB; IF; FCM
Specie Reactivity Human
Sensitivity 6.25 ng/mL (25-1600 ng/mL)
Applications ELISA
Specie Reactivity Human
Sensitivity 13.8 pg/mL (31.25-2000 pg/mL)
Applications ELISA
Specie Reactivity Human
Sensitivity 1.29 ng/mL (3.12-200 ng/mL)
Applications ELISA
Specie Reactivity Rat
Sensitivity 1.95 ng/mL (7.8-500 ng/mL)
Applications ELISA
Specie Reactivity Bovine
Sensitivity 0.156-10 ng/mL
Applications ELISA
Clear All
Specie Reactivity Human
Type Recombinant Protein Antigen
Expression Host E. Coli
Applications AC
Specie Reactivity Human
Type Recombinant Enzyme
Expression Host Mouse myeloma cell line, NS0
Applications Enzyme Activity Assays
Specie Reactivity Human
Type Recombinant Protein
Expression Host E.coli
Applications WB; ELISA; IP
Specie Reactivity Human
Type Recombinant Protein
Expression Host E.coli/Mammalian cell/Baculovirus
Applications WB; ELISA
Specie Reactivity Rat
Type Recombinant Protein
Expression Host Yeast
Applications WB; ELISA
Specie Reactivity Rat
Type Recombinant Protein
Expression Host E.coli/Mammalian cell/Baculovirus
Applications WB; ELISA
Specie Reactivity Human
Purity >85%
Applications Immunogen
Specie Reactivity Human
Species of Lysate 293T Cells
Application Western Blotting (WB)
Clear All
Specie Reactivity Human
Type Expression Plasmid
Vector pCMV6-Entry
Tag Myc-DDK
Specie Reactivity Human
Type Expression Plasmid
Vector pLenti-C-Myc-DDK
Tag Myc-DDK
Specie Reactivity Human
Type Expression Plasmid
Vector pLenti-C-mGFP
Tag mGFP
Specie Reactivity Human
Type Expression Plasmid
Vector pLenti-C-Myc-DDK-P2A-Puro
Tag Myc-DDK
Specie Reactivity Human
Type Expression Plasmid
Vector Lenti-C-mGFP-P2A-Puro
Tag mGFP
Specie Reactivity Human
Type Lentiviral Particle
Vector pLenti-C-Myc-DDK
Tag Myc-DDK
Specie Reactivity Human
Type Lentiviral Particle
Vector pLenti-C-mGFP
Tag mGFP
Specie Reactivity Human
Type Lentiviral Particle
Vector pLenti-C-Myc-DDK-P2A-Puro
Tag Myc-DDK
Specie Reactivity Human
Type Lentiviral Particle
Vector pLenti-C-mGFP-P2A-Puro
Tag mGFP
Specie Reactivity Human
Type Expression Plasmid
Vector pCMV6-Entry
Tag Myc-DDK
Specie Reactivity Human
Type Expression Plasmid
Vector pLenti-C-mGFP
Tag mGFP
Specie Reactivity Human
Type Expression Plasmid
Vector pLenti-C-Myc-DDK-P2A-Puro
Tag Myc-DDK
Specie Reactivity Human
Type Expression Plasmid
Vector pLenti-C-mGFP-P2A-Puro
Tag mGFP
Specie Reactivity Human
Type Expression Plasmid
Vector pLenti-C-Myc-DDK
Tag Myc-DDK
Specie Reactivity Human
Type Lentiviral Particle
Vector pLenti-C-Myc-DDK
Tag Myc-DDK
Specie Reactivity Human
Type Lentiviral Particle
Vector pLenti-C-mGFP
Tag mGFP
Specie Reactivity Human
Type Lentiviral Particle
Vector pLenti-C-Myc-DDK-P2A-Puro
Tag Myc-DDK
Specie Reactivity Human
Type Lentiviral Particle
Vector pLenti-C-mGFP-P2A-Puro
Tag mGFP
Specie Reactivity Human
Type Expression Plasmid
Vector pCMV6-AC-GFP
Tag GFP
Specie Reactivity Human
Type Expression Plasmid
Vector pCMV6-AC-GFP
Tag GFP
Specie Reactivity Human
Type Expression Plasmid
Vector pCMV6-XL4
Specie Reactivity Human
Type Expression Plasmid
Vector pCMV6-XL5
Specie Reactivity Rat
Type Expression Plasmid
Vector pCMV6-Entry
Tag Myc-DDK
Specie Reactivity Rat
Type Expression Plasmid
Vector pLenti-C-Myc-DDK-P2A-Puro
Tag Myc-DDK
Specie Reactivity Rat
Type Expression Plasmid
Vector pLenti-C-mGFP-P2A-Puro
Tag GFP
Specie Reactivity Rat
Type Lentiviral Particle
Vector pLenti-C-Myc-DDK-P2A-Puro
Tag Myc-DDK
Specie Reactivity Rat
Type Lentiviral Particle
Vector pLenti-C-mGFP-P2A-Puro
Tag GFP
Specie Reactivity Rat
Type Expression Plasmid
Vector pCMV6-Entry
Product List Background

Background

Complement C1s, a highly specific SP (EC 3.4.21.42), mediates proteolytic activity of the C1 complex towards its complement substrates C4 and C2. C1s cleaves a single Arg-Ala bond in C4 and lead to the formation of C4a and C4b, it also results in a single Arg-Lys bond in C2 to produce C2a and C2b. Besides, the generation of the C3 convertase C4bC2a requires binding of C2 to C4b before cleavage by C1s. In addition, there are some noncomplement C1s protein substrates, such as heavy chain of the major histocompatibility complex class I antigens, β2-microglobulin, low-density lipoprotein receptor-related protein 6 (LRP6) and insulin-like growth factor-binding protein. C1s has also been proven to cleave the nuclear protein high-mobility group box 1, which is an alarmin released from apoptotic cells.

Fig. 1 C1s involved in alternative pathway. (By Rantes, oringinally at pl.wikipedia, https://commons.wikimedia.org/wiki/File:Droga_klasyczna.png)

C1r binds to C1s and become the C1r2, C1s2 complex, which then binds to C1q. In the previous studies, it has demonstrated that patients with C1r or C1s deficiency have obviously decreased concentrations of the deficient protein (<1% of normal) and levels of the related protein that are 20% to 50% of normal. What’s more, C1r- or C1s-deficient patients are unable to activate C3 and C5 via C9 by the classical pathway therefore have decreased C3b-dependent opsonizing activity.

Reference

  1. From Wikipedia: By Rantes, oringinally at pl.wikipedia, CC BY-SA 3.0 https://commons.wikimedia.org/wiki/File:Droga_klasyczna.png
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