C2

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Host Animal Mouse
Specie Reactivity Human
Antibody Clone CTJS-783
Isotype IgG2aκ
Applications WB; ELISA; IHC
Host Animal Mouse
Specie Reactivity Human
Antibody Clone CTJS-199
Isotype IgG1κ
Applications ELISA; WB
Host Animal Mouse
Specie Reactivity Human
Antibody Clone CTJS-485
Isotype IgG2bκ
Applications ELISA
Host Animal Mouse
Specie Reactivity Human
Antibody Clone CTJS-24
Isotype IgG2a Lambda
Applications ELISA
Host Animal Goat
Specie Reactivity Human
Isotype IgG
Applications WB; IP; ELISA
Host Animal Rabbit
Specie Reactivity Human
Isotype IgG
Applications WB; IF
Host Animal Mouse
Specie Reactivity Human
Antibody Clone CTJS-566
Isotype IgG1κ
Applications ELISA
Host Animal Goats
Isotype IgG
Applications Western Blots; ELISA; Immunodiffusion
Host Animal Rabbit
Specie Reactivity Human
Antibody Clone TJL-27
Isotype IgG
Applications ELISA
Host Animal Rabbit
Specie Reactivity Human
Antibody Clone TJL-28
Isotype IgG
Applications ELISA
Host Animal Mouse
Specie Reactivity Human
Antibody Clone TJL-29
Isotype IgG2A
Applications WB; IP
Host Animal Mouse
Specie Reactivity Human
Antibody Clone TJL-30
Isotype IgG2a Kappa
Applications WB; IP; IF; IHC; ELISA
Host Animal Mouse
Specie Reactivity Human
Antibody Clone TJL-30
Isotype IgG2a Kappa
Applications IP
Host Animal Mouse
Specie Reactivity Human
Antibody Clone TJL-30
Isotype IgG2a Kappa
Applications WB; IHC; ELISA
Host Animal Mouse
Specie Reactivity Human
Antibody Clone TJL-30
Isotype IgG2a Kappa
Applications IF; IHC; FCM
Host Animal Mouse
Specie Reactivity Human
Antibody Clone TJL-30
Isotype IgG2a Kappa
Applications IF; IHC; FCM
Host Animal Mouse
Specie Reactivity Human
Antibody Clone TJL-30
Isotype IgG2a Kappa
Applications WB; IF; IHC; FCM
Host Animal Mouse
Specie Reactivity Human
Antibody Clone TJL-30
Isotype IgG2a Kappa
Applications WB; IF; IHC; FCM
Host Animal Mouse
Specie Reactivity Human
Antibody Clone TJL-30
Isotype IgG2a Kappa
Applications WB; IF; IHC; FCM
Host Animal Mouse
Specie Reactivity Human
Antibody Clone TJL-30
Isotype IgG2a Kappa
Applications WB; IF; IHC; FCM
Host Animal Mouse
Specie Reactivity Human
Antibody Clone TJL-30
Isotype IgG2a Kappa
Applications WB; IF; FCM
Host Animal Mouse
Specie Reactivity Human
Antibody Clone TJL-30
Isotype IgG2a Kappa
Applications WB; IF; FCM
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Specie Reactivity Human
Sensitivity 2.7 ng/mL (7.8-500 ng/mL)
Applications ELISA
Specie Reactivity Human
Sensitivity 15.6 ng/mL (15.6-250 ng/mL)
Applications ELISA
Specie Reactivity Mouse
Sensitivity 18.75 ng/mL (18.75-300 ng/mL)
Applications ELISA
Specie Reactivity Rat
Sensitivity 0.07 ng/mL (0.19-12 ng/mL)
Applications ELISA
Specie Reactivity Chicken
Sensitivity 0.375 ng/mL (6.25-400 ng/mL)
Applications ELISA
Specie Reactivity Rabbit
Sensitivity 0.1 ng/mL (1.0-25 ng/mL)
Applications ELISA
Specie Reactivity Bovine
Sensitivity 7.8 ng/mL (15.6-1000 ng/mL)
Applications ELISA
Specie Reactivity Guinea Porcine
Sensitivity 0.1 ng/mL (1.0-25 ng/mL)
Applications ELISA
Specie Reactivity Dog
Sensitivity 0.1 ng/mL (1.0-25 ng/mL)
Applications ELISA
Specie Reactivity Monkey
Sensitivity 0.188 ng/mL (0.313-20 ng/mL)
Applications ELISA
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Specie Reactivity Human
Type Recombinant Enzyme
Expression Host Mouse myeloma cell line, NS0
Applications Enzyme Activity Assays
Specie Reactivity Human
Type Recombinant Protein
Expression Host E. Coli
Applications WB; ELISA; IP
Specie Reactivity Rat
Type Recombinant Protein
Expression Host E. Coli
Applications WB; ELISA; IP
Specie Reactivity Mouse
Type Recombinant Enzyme
Expression Host Mouse myeloma cell line, NS0
Applications Enzyme Activity Assays
Specie Reactivity Human
Type Native Protein
Applications Functional Assays
Specie Reactivity Mouse
Type Recombinant Protein
Expression Host Yeast
Applications WB; ELISA
Specie Reactivity Mouse
Type Recombinant Protein
Expression Host E.coli/Mammalian cell/Baculovirus
Applications WB; ELISA
Type Native Protein
Expression Host Normal human serum
Applications Functional Assays
Clear All
Specie Reactivity Mammalian
Purity >90%
Applications Blocking; IHC; WB
Specie Reactivity Mammalian
Purity >90%
Applications Blocking; IHC; WB
Specie Reactivity Human
Purity >90%
Applications Blocking; WB
Specie Reactivity Human
Purity >90%
Applications Blocking; WB
Specie Reactivity Human; Hamster
Purity >90%
Applications Blocking
Specie Reactivity Human; Mouse;Rat
Purity >90%
Applications IHC; WB
Specie Reactivity Human; Mouse;Rat
Purity >90%
Applications IHC; WB
Specie Reactivity Human
Species of Lysate Escherichia coli (E. coli)
Application Western Blotting (WB); Control (Ct)
Specie Reactivity Human
Species of Lysate 293T Cells
Application Western Blotting (WB)
Specie Reactivity Human
Species of Lysate 293T Cells
Application Western Blotting (WB)
Specie Reactivity Human
Species of Lysate Human Cells
Application Western Blotting (WB)
Specie Reactivity Mouse
Species of Lysate Human Cells
Application Western Blotting (WB)
Clear All
Specie Reactivity Human
Type Expression Plasmid
Vector pCMV6-AC-GFP
Tag GFP
Specie Reactivity Human
Type Expression Plasmid
Vector pCMV6-Entry
Tag Myc-DDK
Specie Reactivity Human
Type Expression Plasmid
Vector pLenti-C-Myc-DDK-P2A-Puro
Tag Myc-DDK
Specie Reactivity Human
Type Expression Plasmid
Vector pLenti-C-mGFP-P2A-Puro
Tag mGFP
Specie Reactivity Human
Type Lentiviral Particle
Vector pLenti-C-Myc-DDK-P2A-Puro
Tag Myc-DDK
Specie Reactivity Human
Type Lentiviral Particle
Vector pLenti-C-mGFP-P2A-Puro
Tag mGFP
Specie Reactivity Human
Type Expression Plasmid
Vector pCMV6-Entry
Tag Myc-DDK
Specie Reactivity Human
Type Expression Plasmid
Vector pLenti-C-Myc-DDK
Tag Myc-DDK
Specie Reactivity Human
Type Expression Plasmid
Vector pLenti-C-mGFP
Tag mGFP
Specie Reactivity Human
Type Expression Plasmid
Vector pLenti-C-Myc-DDK-P2A-Puro
Tag Myc-DDK
Specie Reactivity Human
Type Expression Plasmid
Vector pLenti-C-mGFP-P2A-Puro
Tag mGFP
Specie Reactivity Human
Type Lentiviral Particle
Vector pLenti-C-Myc-DDK
Tag Myc-DDK
Specie Reactivity Human
Type Lentiviral Particle
Vector pLenti-C-mGFP
Tag mGFP
Specie Reactivity Human
Type Lentiviral Particle
Vector pLenti-C-Myc-DDK-P2A-Puro
Tag Myc-DDK
Specie Reactivity Human
Type Lentiviral Particle
Vector pLenti-C-mGFP-P2A-Puro
Tag mGFP
Specie Reactivity Human
Type Expression Plasmid
Vector pCMV6-Entry
Tag Myc-DDK
Specie Reactivity Human
Type Expression Plasmid
Vector pCMV6-AC-GFP
Tag GFP
Specie Reactivity Human
Type Expression Plasmid
Vector pCMV6-AC-GFP
Tag GFP
Specie Reactivity Human
Type Expression Plasmid
Vector pCMV6-Entry
Tag Myc-DDK
Specie Reactivity Human
Type Expression Plasmid
Vector pCMV6-AC-GFP
Tag GFP
Specie Reactivity Human
Type Expression Plasmid
Vector pCMV6-Entry
Tag Myc-DDK
Specie Reactivity Human
Type Expression Plasmid
Vector pCMV6-AC-GFP
Tag GFP
Specie Reactivity Human
Type Expression Plasmid
Vector pCMV6-Entry
Tag Myc-DDK
Specie Reactivity Human
Type Expression Plasmid
Vector pLenti-C-Myc-DDK-P2A-Puro
Tag Myc-DDK
Specie Reactivity Human
Type Expression Plasmid
Vector pLenti-C-mGFP-P2A-Puro
Tag mGFP
Specie Reactivity Human
Type Lentiviral Particle
Vector pLenti-C-Myc-DDK-P2A-Puro
Tag Myc-DDK
Specie Reactivity Human
Type Lentiviral Particle
Vector pLenti-C-mGFP-P2A-Puro
Tag mGFP
Specie Reactivity Human
Type Expression Plasmid
Vector pCMV6-AC-GFP
Tag GFP
Specie Reactivity Human
Type Expression Plasmid
Vector pCMV6-XL4
Specie Reactivity Human
Type Expression Plasmid
Vector pCMV6-Entry
Specie Reactivity Human
Type Expression Plasmid
Vector pCMV6-Entry
Specie Reactivity Human
Type Expression Plasmid
Vector pCMV6-Entry
Specie Reactivity Human
Type Expression Plasmid
Vector pCMV6-Entry
Specie Reactivity Human
Type Expression Plasmid
Vector pCMV6-Entry
Specie Reactivity Mouse
Type Expression Plasmid
Vector pCMV6-AC-GFP
Tag GFP
Specie Reactivity Mouse
Type Expression Plasmid
Vector pCMV6-Entry
Tag Myc-DDK
Specie Reactivity Mouse
Type Expression Plasmid
Vector pLenti-C-Myc-DDK-P2A-Puro
Tag Myc-DDK
Specie Reactivity Mouse
Type Expression Plasmid
Vector pLenti-C-mGFP-P2A-Puro
Tag mGFP
Specie Reactivity Mouse
Type Lentiviral Particle
Vector pLenti-C-Myc-DDK-P2A-Puro
Tag Myc-DDK
Specie Reactivity Mouse
Type Lentiviral Particle
Vector pLenti-C-mGFP-P2A-Puro
Tag GFP
Specie Reactivity Mouse
Type Expression Plasmid
Vector PCMV6-Kan/Neo
Specie Reactivity Rat
Type Expression Plasmid
Vector pCMV6-Entry
Specie Reactivity Rat
Type Expression Plasmid
Vector pCMV6-Entry
Tag Myc-DDK
Specie Reactivity Rat
Type Expression Plasmid
Vector pLenti-C-Myc-DDK-P2A-Puro
Tag Myc-DDK
Specie Reactivity Rat
Type Expression Plasmid
Vector pLenti-C-mGFP-P2A-Puro
Tag mGFP
Specie Reactivity Rat
Type Lentiviral Particle
Vector pLenti-C-Myc-DDK-P2A-Puro
Tag Myc-DDK
Specie Reactivity Rat
Type Lentiviral Particle
Vector pLenti-C-mGFP-P2A-Puro
Tag GFP
Product List Background Application Related Service FAQ Resources

Background

Complement C2 is an important protein in the complement system which regulates the complement activation of classical and MBL pathways. C2 can bind to membrane-bound C4b and is then cleaved by C1s or MASP2, forming C2b and C4bC2a (a C3-convertase). This is a key step in complement activation. C3 proteins are cleaved by C3 convertase and lead to the generation of crucial effector molecules – C3a and C3b. Besides, C2 is related to first-line defense against microbial infection that is important for detection and clearance of the invading pathogens.

Fig. 1 Complement C2 structure. (From Wikipedia: By Emw - Own work, https://commons.wikimedia.org/wiki/File:Protein_C2_PDB_2i6q.png) Fig. 1 Complement C2 structure.1

In general, the activation of the alternative pathway is C3 dependent, which is usually intact in C2 deficiency and can trigger the production of the membrane attack complex (MAC) independently of C2. Nevertheless, in some situations, in the absence of C2, C3 is not efficiently cleaved leading to a limited deposition of C3 fragments on immune complexes and the surface of apoptotic cells. Thus, circulating apoptotic cells turned into a source of self-antigen for auto-antibodies that participate in the generation of immune complexes. The immune complexes are deposited throughout the body, potentially resulting in localized inflammatory reactions in joints and kidneys, and finally causing renal disease from chronic activation of the complement system.

Reference

  1. From Wikipedia: By Emw - Own work, CC BY-SA 3.0 https://commons.wikimedia.org/wiki/File:Protein_C2_PDB_2i6q.png

Application

  • We have a wide range of Complement C2 antibodies that are primarily used for research purposes. These antibodies have been designed to bind with high specificity to human, mouse, rat, among others, Complement C2 varieties. These antibodies can be used to detect C2 expression levels in biological samples, understand the complement pathway, investigate autoimmune conditions, and for the development of potential therapeutic solutions. Our monoclonal and polyclonal antibodies can be used in various laboratory techniques like Western blot, Flow cytometry, Immunofluorescence, ELISA, and Immunohistochemistry.
  • We produce recombinant Complement C2 proteins and peptides for research use. They can be used in protein expression studies, as control samples in assays, for structure-function studies, or as antigens in the production of antibodies. They can help explore a range of biological processes, such as the complement pathway, innate immunity, and inflammatory responses.
  • We offer a variety of assay kits for use in assays like ELISA, IHC, or Western Blotting. These include different types of enzyme-linked secondary antibodies, substrate solutions, and buffer solutions optimized for signal detection. With these reagents, researchers can visualize the interaction and localization of Complement C2 protein in the cell, which can aid in studying various immunological diseases, like autoimmune disorders.

Our foremost priority is to ensure the reliability and top-notch quality of these products. By adopting stringent quality control measures, we can promise that our Complement C2 related products deliver consistent and reliable results to researchers.

They are all intended for laboratory research use and are not suitable for diagnostic or therapeutic applications in humans or animals.

Related Service

FAQ

A: Generally, antibodies should be stored at -20°C or -80°C and avoid repeated freeze-thaw cycles. However, storage conditions may vary based on the specific product, so it is essential to refer to the product manual or datasheet for precise guidelines.

A: Our antibodies typically exhibit high specificity against Complement C2, with minimal cross-reactivity with other proteins. Detailed information can be found on the product datasheet.

A: The purity of our proteins and peptides typically ranges from >85% to >98%. For exact purity, please refer to the Certificate of Analysis provided with each lot. Complement C2 peptides can be used as controls for blocking antibody binding during cell staining or Western blotting experiments.

A: Yes, we can custom synthesize peptides according to your requirements.

A: Our Complement C2 products are labeled "For research use only. Not for use in diagnostic procedures." They are not intended for use in medical diagnosis or treatment.

A: We stand by the quality of our products and provide technical support for all of our offerings. We offer a guarantee for the stated applications and species as per our Terms and Conditions..

Resources

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For Research Use Only.