C5

Clear All
Host Animal Mouse
Specie Reactivity Human
Antibody Clone CTJS-35
Isotype IgG2a
Applications WB; ELISA; Neut; Funcs
Host Animal Mouse
Specie Reactivity Human
Antibody Clone CTJS-669
Isotype IgG2a
Applications ELISA; Funcs; IA
Host Animal Mouse
Specie Reactivity Human
Antibody Clone CTJS-757
Isotype IgG2a
Applications WB; IA
Host Animal Mouse
Specie Reactivity Human
Antibody Clone CTJS-516
Isotype IgG1κ
Applications WB; ELISA
Host Animal Mouse
Specie Reactivity Human
Antibody Clone CTJS-342
Isotype IgG1κ
Applications WB; ELISA
Host Animal Rat
Specie Reactivity Mouse
Antibody Clone CTJS-491
Isotype IgG2a
Applications WB; ELISA; Neut
Host Animal Rabbit
Specie Reactivity Human
Isotype IgG
Applications IHC
Host Animal Rabbit
Specie Reactivity Mouse
Isotype IgG
Applications WB
Host Animal Recombinant
Specie Reactivity Human
Antibody Clone CTJS-536
Isotype IgG2/4, κ
Applications ELISA
Host Animal Goats
Isotype IgG
Applications Western Blots; ELISA; Immunodiffusion
Clear All
Specie Reactivity Human
Sensitivity 15.1 pg/mL (31.2-2000 pg/mL)
Applications ELISA
Specie Reactivity Human
Sensitivity 1.39 ng/mL (3.12-200 ng/mL)
Applications ELISA
Specie Reactivity Human
Sensitivity 1.45 ng/mL (3.12-200 ng/mL)
Applications ELISA
Specie Reactivity Primate
Sensitivity 53 pg/mL (0.156-10 ng/mL)
Applications ELISA
Specie Reactivity Mouse
Sensitivity 4.4 ng/mL (12.5-800 ng/mL)
Applications ELISA
Specie Reactivity Mouse
Sensitivity 0.06 ng/mL (0.25-16 ng/mL)
Applications ELISA
Specie Reactivity Mouse
Sensitivity 0.113 ng/mL (0.312-20 ng/mL)
Applications ELISA
Specie Reactivity Rat
Sensitivity 2.34 ng/mL (9.38-600 ng/mL)
Applications ELISA
Specie Reactivity Rabbit
Sensitivity 1.875 ng/mL (3.125-200 ng/mL)
Applications ELISA
Specie Reactivity Chicken
Sensitivity 1.875 ng/mL (3.125-200 ng/mL)
Applications ELISA
Specie Reactivity Porcine
Sensitivity 46.875 pg/mL (78.125-5000 pg/mL)
Applications ELISA
Specie Reactivity Porcine
Sensitivity 0.78-50 ng/mL
Applications ELISA
Specie Reactivity Guinea Porcine
Sensitivity 0.375 ng/mL (0.625-40 ng/mL)
Applications ELISA
[Cat#: CTK-314] Dog Complement C5 ELISA Kit
Specie Reactivity Canine
Sensitivity 1.0 ng/mL (50-1000 ng/mL)
Applications ELISA
Specie Reactivity Bovine
Sensitivity 0.156 ng/mL (0.625-40 ng/mL)
Applications ELISA
Specie Reactivity Monkey
Sensitivity 0.156 ng/mL (0.625-40 ng/mL)
Applications ELISA
Clear All
Specie Reactivity Human
Type Recombinant Protein
Expression Host Wheat Germ (in vitro)
Applications WB; ELISA; PA; AP
Specie Reactivity Human
Type Recombinant Protein Antigen
Expression Host E. Coli
Applications AC
Specie Reactivity Human
Type Native Protein
Applications Functional Assays
Specie Reactivity Human
Type Recombinant Protein
Expression Host E.coli
Applications Positive Control; Immunogen; WB
Specie Reactivity Human
Type Recombinant Protein
Expression Host HEK293 Cells
Applications WB; IA
Specie Reactivity Rat
Type Recombinant Protein
Expression Host Yeast
Applications WB; ELISA
Specie Reactivity Rat
Type Recombinant Protein
Expression Host E.coli
Applications WB; ELISA; IP
Specie Reactivity Rat
Type Recombinant Protein
Expression Host E.coli
Applications WB; ELISA; IP
Specie Reactivity Human
Purity >90%
Applications Blocking
[Cat#: CTI-006] Complement C5-IN-1
CAS No. 2365402-67-9
Product Overview This product is a potent C5 inhibitor, it interacts with C5 to prevent its cleavage by the C5 convertase and blocks zymosan-induced the membrane-attack complex (MAC) deposition in 50% human whole blood with an IC50 of 0.77 µM.
[Cat#: CTWZ-0124-WZ16] Anti-Human C5 Aptamer
Affinity (Kd) 1-50 nM
Chemical Modification 2'-fluoro pyrimidines
Clear All
Specie Reactivity Human
Type Expression Plasmid
Vector pCMV6-AC-GFP
Tag GFP
Specie Reactivity Human
Type Expression Plasmid
Vector pCMV6-Entry
Tag Myc-DDK
Specie Reactivity Human
Type Expression Plasmid
Vector pLenti-C-Myc-DDK
Tag Myc-DDK
Specie Reactivity Human
Type Expression Plasmid
Vector pLenti-C-Myc-DDK-P2A-Puro
Tag Myc-DDK
Specie Reactivity Human
Type Lentiviral Particle
Vector pLenti-C-Myc-DDK
Tag Myc-DDK
Specie Reactivity Human
Type Lentiviral Particle
Vector pLenti-C-Myc-DDK-P2A-Puro
Tag Myc-DDK
Specie Reactivity Human
Type Expression Plasmid
Vector pCMV6-Entry
Product List Background

Background

The complement system is a crucial part of the innate immune system, it recognizes many non-self structures present on pathogens or altered self cells. The initiation of the complement system elicits proteolytic cascades which finally leads to the cleavage of the C5 protein into two fragments, C5a and C5b. C5a is a small anaphylatoxin that can cause a variety of biological responses upon binding to the 7TM receptors C5aR and the C5L2. However, C5b is a big fragment nucleates generation of the membrane attack complex which enables to kill susceptible pathogens via the production of a pore structure in association with complement components C6, C7, C8, and C9.

Activation of C5 by C5 convertase leads to the generation of C5a and C5b.Fig. 1 Activation of C5 by C5 convertase leads to the generation of C5a and C5b.1, 2

Generally, a range of regulatory molecules help to regulate C5 mediated immune responses towards host cells. However, in many major inflammatory conditions (e.g., sepsis and arthritis), C5a is demonstrated to contribute significantly to disease etiology. In the past years, several attempts have been made to develop inhibitors of complement C5 activation. These inhibitors target factors upstream of C5, such as complement components C5, C5 convertase, C5a, and C5b, as well as C5a receptor. Nowadays, a full range of types of antibodies and compounds have actively been developed. These inhibitors may be effective at treating various inflammatory diseases involving complements.

Click the following targets to view our C5 product lists.

References

  1. Horiuchi, Takahiko, and Hiroshi Tsukamoto. "Complement-targeted therapy: development of C5-and C5a-targeted inhibition." Inflammation and regeneration 36 (2016): 1-5.
  2. under Open Access license CC BY 4.0, without modification
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For Research Use Only.