Human 15-PGDH ELISA Matched Antibody Pair Set [ABP-Q-04-183] (CAT#: ABP-Q-04-183)

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Human 15-PGDH antibody pair set for ELISA useCapture Antibody: rabbit anti-Human HPGD/15-PGDH monoclonal antibodyDetection Antibody: rabbit anti-Human HPGD/15-PGDH monoclonal antibody conjugated to HRP

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Type Size Price Quantity  
Antibody Pair Set-Package 1 5 × 96 tests $1,120.00
Antibody Pair Set-Package 2 15 × 96 tests $2,331.43
Datasheet
MSDS
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Lot Number

Antigen Detail
Target15-PGDH
Description15-hydroxyprostaglandin dehydrogenase [NAD+], also known as Prostaglandin dehydrogenase 1, HPGD, and PGDH1, is a member of the short-chain dehydrogenases/reductases (SDR) family. Prostaglandins (PGs) play a key role in the onset of labor in many species and regulate uterine contractility and cervical dilatation. Therefore, the regulation of prostaglandin output by PG synthesizing and metabolizing enzymes in the human myometrium may determine uterine activity patterns in human labor both at preterm and at term. Prostaglandin dehydrogenase (PGDH) metabolizes prostaglandins (PGs) to render them inactive. HPGD is down-regulated by cortisol, dexamethasone, and betamethasone and down-regulated in colon cancer. It is up-regulated by TGFB1. HPGD contributes to the regulation of events that are under the control of prostaglandin levels. HPGD catalyzes the NAD-dependent dehydrogenation of lipoxin A4 to form 15-oxo-lipoxin A4. and inhibits in vivo proliferation of colon cancer cells. Defects in HPGD are the cause of primary hypertrophic osteoarthropathy autosomal recessive (PHOAR), cranio-osteoarthropathy (COA), and isolated congenital nail clubbing.
Species ReactivityHuman

Capture Antibody
Capture ClonalityMonoclonal
Host SpeciesRabbit
CloneIV0172
PurificationAffinity Chromatography
BufferPrior to lyophilization: PBS, pH 7.4
ApplicationELISA

Detection Antibody
Det-ClonalityMonoclonal
Host SpeciesRabbit
ConjugationHRP
CloneRD10231
PurificationAffinity Chromatography
BufferPrior to lyophilization: PBS, containing 50 % HRP-Protector

General Product Property
Product OverviewHuman 15-PGDH antibody pair set for ELISA use
Capture Antibody: rabbit anti-Human HPGD/15-PGDH monoclonal antibody
Detection Antibody: rabbit anti-Human HPGD/15-PGDH monoclonal antibody conjugated to HRP
SpecificityQuantitative determination of Human 15-PGDH
Range31.25-2000 pg/mL
Research AreaInflammation; Innate Immunity
ApplicationELISA
Application NotesOptimal dilutions should be determined experimentally by the user.
FormLyophilized
StorageAvoid repeated freeze/thaw cycles. Store at 2-8°C for short term. Aliquot and store at -20°C for long term storage.
Size1 Set
Sample TypeSerum; Supernatant; Urine; Cell lysate; Plasma; Tissue Homogenates
Usage StatementAvailable for Research Use Only. Not for use in therapeutic or diagnostic applications.

Target Overview
Gene SymbolHPGD
Full Name15-Hydroxyprostaglandin Dehydrogenase
BackgroundThis gene encodes a member of the short-chain nonmetalloenzyme alcohol dehydrogenase protein family. The encoded enzyme is responsible for the metabolism of prostaglandins, which function in a variety of physiologic and cellular processes such as inflammation. Mutations in this gene result in primary autosomal recessive hypertrophic osteoarthropathy and cranioosteoarthropathy. Multiple transcript variants encoding different isoforms have been found for this gene.
Alternative Names15-PGDH; PHOAR1
Gene ID3248
Uniprot IDP15428

For Research Use Only.

Application
AgonistAgonist
AntagonistAntagonist
ApopApoptosis Assay
BlockBlocking
BIBioimaging
ChIPChromatin Immunoprecipitation
Co-IPCo-Immunoprecipitation
CytCytotoxicity Assay
CellActCell Activiation
CellDiffCell Differentiation
DBDot Blot
ECLElectrochemiluminescence
ELISAEnzyme-Linked Immunosorbent Assay
Indirect ELISAIndirect ELISA
Sandwich ELISASandwich ELISA
Competitive ELISACompetitive ELISA
ELISPOTEnzyme-linked Immunosorbent Spot
FuncSFunctional Studies
FACSFluorescence-activated cell sorting
FCFlow Cytometry
FIAFluorescence Immunoassay
FRETFluorescence Resonance Energy Transfer Microscopy
GSGel Shift
HAHemagglutination Assay
HPLCHigh Performance Liquid Chromatography
IAImmunoassay
IBImmunoblotting
ICCImmunocytochemistry
IEMImmuno-Electron Microscopy
IFImmunofluorescence
IHCImmunohistochemistry
IHC-FrImmunohistochemistry-Frozen
IHC-PImmunohistochemistry-Paraffin
IPImmunoprecipitation
IRMAImmunoradiometric Assay
ISHIn Situ Hybridization
InhibitInhibition Assay
Live-cell imagingLive-cell Imaging Assay
MeDIPMethylated DNA Immunoprecipitation
MAMicroagglutination Assay
MSMass Spectrometry
NeutNeutralization Assay
PepArrPeptide Array
PPProtein Purification
PGProteogenomics
RIRadial Immunodiffusion
RIARadioimmunoassay
RIPRadioimmunoprecipitation
StimStimulation Assay
TCAT-Cell Activation Assay
TRFTime-Resolved Fluorescence
TCTissue Culture
TBTurbidimetry
PBAProtein Binding Assay
PLAProximity Ligation Assay
SDS-PAGESodium Dodecyl Sulfate Polyacrylamide Gel Electrophoresis
SPRSurface Plasmon Resonance
WBWestern Blot
CLIAChemiluminescent Immunoassay
CLEIAChemiluminescent Enzyme Immunoassay
ECLIAElectrochemiluminescence Immunoassay
TRFIATime-resolved Fluorescence Immunoassay
LIALaser Immunoassay
MLEIAMicroparticle Luminescence Enzyme Immunoassay
LETIALatex Particle-Enhanced Turbidimetric Immunoassay
LFIALateral Flow Immunoassay
GICAColloidal Gold immunochomatography Assay
ICTImmune Chromatographic Test
LTIALatex Turbidimetric Immunoassay
CMIAChemiluminescence microparticle immuno assay
IACInnuno-Affinity Chromatography
TIATurbidimetric Immunoassay
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