Human ACAT2 Matched Antibody Pair set for ELISA useCapture Antibody: Mouse monoclonal anti-ACTA2, IgG2b KappaDetection Antibody: Mouse monoclonal anti-ACTA2, IgG1 Kappa
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Antigen Detail | |
|---|---|
| Target | ACAT2 |
| Description | Acetyl-CoA acetyltransferase, cytosolic, also known as cytosolic acetoacetyl-CoA thiolase, is an enzyme that in humans is encoded by the ACAT2 (acetyl-Coenzyme A acetyltransferase 2) gene. Acetyl-Coenzyme A acetyltransferase 2 is an acetyl-CoA C-acetyltransferase enzyme which is involved in lipid metabolism. |
| Species Reactivity | Human |
Capture Antibody | |
|---|---|
| Capture Clonality | Monoclonal |
| Host Species | Mouse |
| Clone | IV01573 |
| Isotype | IgG2b, kappa |
| Purification | Affinity chromatography |
| Buffer | PBS, pH 7.4, containing 0.1% Proclin 300 |
| Application | ELISA |
Detection Antibody | |
|---|---|
| Det-Clonality | Monoclonal |
| Host Species | Mouse |
| Conjugation | Biotin |
| Clone | RD10121 |
| Isotype | IgG1, kappa |
| Purification | Affinity chromatography |
| Buffer | PBS, pH 7.4 |
General Product Property | |
|---|---|
| Product Overview | Human ACAT2 Matched Antibody Pair set for ELISA use Capture Antibody: Mouse monoclonal anti-ACTA2, IgG2b Kappa Detection Antibody: Mouse monoclonal anti-ACTA2, IgG1 Kappa |
| Specificity | Validated for detecting natural and recombinant human ACAT2 |
| Research Area | Lipid metabolism |
| Application | ELISA |
| Application Notes | Optimal dilutions should be determined experimentally by the user. |
| Form | Lyophilized |
| Storage | Avoid repeated freeze/thaw cycles. Store at 2-8°C for short term. Aliquot and store at -20°C for long term storage. |
| Size | 1 Set |
| Sample Type | Serum; Supernatant; Urine; Cell lysate; Plasma; Tissue Homogenates |
| Usage Statement | Available for Research Use Only. Not for use in therapeutic or diagnostic applications. |
Target Overview | |
|---|---|
| Gene Symbol | ACCS |
| Full Name | 1-Aminocyclopropane-1-Carboxylate Synthase Homolog (Inactive) |
| Background | This enzyme belongs to the family of lyases, specifically carbon-sulfur lyases. The systematic name of this enzyme class is S-adenosyl-L-methionine methylthioadenosine-lyase(1-aminocyclopropane-1-carboxylate-forming). Other names in common use include 1-aminocyclopropanecarboxylate synthase, 1-aminocyclopropane-1-carboxylic acid synthase, 1-aminocyclopropane-1-carboxylate synthetase, aminocyclopropanecarboxylic acid synthase, aminocyclopropanecarboxylate synthase, ACC synthase, and S-adenosyl-L-methionine methylthioadenosine-lyase. This enzyme participates in propanoate metabolism. It employs one cofactor, pyridoxal phosphate. |
| Alternative Names | 1-aminocyclopropanecarboxylate synthase; 1-aminocyclopropane-1-carboxylic acid synthase; 1-aminocyclopropane-1-carboxylate synthetase; aminocyclopropanecarboxylic acid synthase; aminocyclopropanecarboxylate synthase; ACC synthase; S-adenosyl-L-methionine methylthioadenosine-lyase; PHACS; ACC Synthase-Like Protein 1; ACS |
| Gene ID | 84680 |
| Uniprot ID | UniProtKB(Q96QU6) |
| HGNC | HGNC(23989) |
| Ensembl | Ensembl(ENSG00000110455) |
| OMIM | OMIM(608405) |
| Involvement in Disease | Diseases associated with ACCS include Pancreatic Acinar Cell Adenocarcinoma and Lung Adenoid Cystic Carcinoma. |
| Function | ACC Synthase is the key, rate limiting step in ethylene synthesis. Because the up-regulation of ACC-Synthase is what induces fruit ripening and often spoilage there is more research being done on the regulatory mechanisms and biosynthetic pathways of ethylene to avoid spoilage. |
For Research Use Only.
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