Human ALDH1A1 Matched Antibody Pair set for ELISA useCapture Antibody: Rabbit purified polyclonal anti-ALDH1A1Detection Antibody: Mouse monoclonal anti-ALDH1A1, IgG2a Kappa
Specific Inquiry(Note: Please select the requirements to fit you project. If you have any other requirements, please specify. If no specific requirements, you don't need to select any button.)
Antigen Detail | |
|---|---|
| Target | ALDH1A1 |
| Description | Aldehyde dehydrogenase 1 family, member A1, also known as ALDH1A1 or retinaldehyde dehydrogenase 1, is an enzyme that in humans is encoded by the ALDH1A1 gene. ALDH1A1 is a cytosolic enzyme with high affinity for retinal oxidation and acetaldehyde metabolism. |
| Species Reactivity | Human |
Capture Antibody | |
|---|---|
| Capture Clonality | Polyclonal |
| Host Species | Rabbit |
| Purification | Affinity chromatography |
| Buffer | PBS, pH 7.4, containing 0.1% Proclin 300 |
| Application | ELISA |
Detection Antibody | |
|---|---|
| Det-Clonality | Monoclonal |
| Host Species | Mouse |
| Conjugation | Unconjugated |
| Clone | RD10220 |
| Isotype | IgG2a, kappa |
| Purification | Affinity chromatography |
| Buffer | PBS, pH 7.4 |
General Product Property | |
|---|---|
| Product Overview | Human ALDH1A1 Matched Antibody Pair set for ELISA use Capture Antibody: Rabbit purified polyclonal anti-ALDH1A1 Detection Antibody: Mouse monoclonal anti-ALDH1A1, IgG2a Kappa |
| Specificity | Validated for detecting natural and recombinant human ALDH1A1 |
| Research Area | Neurodegenerative disease; Parkinson's disease |
| Application | ELISA |
| Application Notes | Optimal dilutions should be determined experimentally by the user. |
| Form | Lyophilized |
| Storage | Avoid repeated freeze/thaw cycles. Store at 2-8°C for short term. Aliquot and store at -20°C for long term storage. |
| Size | 1 Set |
| Sample Type | Serum; Supernatant; Urine; Cell lysate; Plasma; Tissue Homogenates |
| Usage Statement | Available for Research Use Only. Not for use in therapeutic or diagnostic applications. |
Target Overview | |
|---|---|
| Gene Symbol | ALDH1A1 |
| Full Name | Aldehyde Dehydrogenase 1 Family Member A1 |
| Background | The protein encoded by this gene belongs to the aldehyde dehydrogenase family. Aldehyde dehydrogenase is the next enzyme after alcohol dehydrogenase in the major pathway of alcohol metabolism. There are two major aldehyde dehydrogenase isozymes in the liver, cytosolic and mitochondrial, which are encoded by distinct genes, and can be distinguished by their electrophoretic mobility, kinetic properties, and subcellular localization. This gene encodes the cytosolic isozyme. Studies in mice show that through its role in retinol metabolism, this gene may also be involved in the regulation of the metabolic responses to high-fat diet. [provided by RefSeq, Mar 2011] |
| Alternative Names | Aldehyde Dehydrogenase 1 Family Member A1; Retinaldehyde Dehydrogenase 1; EC 1.2.1.36; RALDH 1; ALDH-E1; RALDH1; ALHDII; ALDH1; PUMB1; ALDC; Epididymis Secretory Sperm Binding Protein Li 53e; Aldehyde Dehydrogenase 1 Family; Member A1; Aldehyde Dehydrogenase Family 1 Member A1; Aldehyde Dehydrogenase; Liver Cytosolic; |
| Gene ID | 216 |
| Uniprot ID | P00352 |
| GeneCards | ALDH1A1 |
| HGNC | 402 |
| Ensembl | ENSG00000165092 |
| OMIM | 100640 |
| Involvement in Disease | Diseases associated with ALDH1A1 include Erythroplakia and Ras-Associated Autoimmune Leukoproliferative Disorder. |
| Function | It is possible to convert/oxidize retinal to retinoic acid. Combines free retina with cellular retinol binding protein (similarity). It may have a wider specificity and oxidize other aldehydes in the body. |
| Related Pathways | Its related pathways are Signaling by GPCR and Cytochrome P450 - arranged by substrate type. |
For Research Use Only.
Related products
