Human ATP1B3 Matched Antibody Pair set for ELISA useCapture Antibody: Mouse monoclonal anti-ATP1B3, IgG2a KappaDetection Antibody: Mouse monoclonal anti-ATP1B3, IgG2a Kappa
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Antigen Detail | |
|---|---|
| Target | ATP1B3 |
| Description | Sodium/potassium-transporting ATPase subunit beta-3 is an enzyme that in humans is encoded by the ATP1B3 gene. ATP1B3 has also been designated as CD298. The protein encoded by this gene belongs to the family of Na+/K+ and H+/K+ ATPases beta chain proteins, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. |
| Species Reactivity | Human |
Capture Antibody | |
|---|---|
| Capture Clonality | Monoclonal |
| Host Species | Mouse |
| Clone | IV01198 |
| Isotype | IgG2a, kappa |
| Purification | Affinity chromatography |
| Buffer | PBS, pH 7.4, containing 0.1% Proclin 300 |
| Application | ELISA |
Detection Antibody | |
|---|---|
| Det-Clonality | Monoclonal |
| Host Species | Mouse |
| Conjugation | Biotin |
| Clone | RD10261 |
| Isotype | IgG2a, kappa |
| Purification | Affinity chromatography |
| Buffer | PBS, pH 7.4 |
General Product Property | |
|---|---|
| Product Overview | Human ATP1B3 Matched Antibody Pair set for ELISA use Capture Antibody: Mouse monoclonal anti-ATP1B3, IgG2a Kappa Detection Antibody: Mouse monoclonal anti-ATP1B3, IgG2a Kappa |
| Specificity | Validated for detecting natural and recombinant human ATP1B3 |
| Research Area | Metabolism |
| Application | ELISA |
| Application Notes | Optimal dilutions should be determined experimentally by the user. |
| Form | Lyophilized |
| Storage | Avoid repeated freeze/thaw cycles. Store at 2-8°C for short term. Aliquot and store at -20°C for long term storage. |
| Size | 1 Set |
| Sample Type | Serum; Supernatant; Urine; Cell lysate; Plasma; Tissue Homogenates |
| Usage Statement | Available for Research Use Only. Not for use in therapeutic or diagnostic applications. |
Target Overview | |
|---|---|
| Gene Symbol | ATP1B3 |
| Full Name | ATPase Na+/K+ Transporting Subunit Beta 3 |
| Background | The protein encoded by this gene belongs to the family of Na+/K+ and H+/K+ ATPases beta chain proteins, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane. The glycoprotein subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes a beta 3 subunit. This gene encodes a beta 3 subunit. A pseudogene exists for this gene, and it is located on chromosome 2. [provided by RefSeq, Jul 2008] |
| Alternative Names | Sodium/Potassium-Dependent ATPase Subunit Beta-3 |
| Gene ID | 483 |
| Uniprot ID | P54709 |
| GeneCards | ATP1B3 |
| HGNC | 806 |
| Ensembl | ENSG00000069849 |
| OMIM | 601867 |
| Involvement in Disease | Diseases associated with ATP1B3 include Newfoundland Rod-Cone Dystrophy. |
| Function | The Na+/K+ ATPase is a membrane protein that is composed of two subunits - alpha and beta. The pump maintains an essential electrochemical gradient within cells through the active transport of sodium (Na+) and potassium (K+) ions. |
| Related Pathways | Its related pathways are Collagen chain trimerization and Cell surface interactions at the vascular wall. |
For Research Use Only.
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