Human EPHA2 Matched Antibody Pair set for ELISA useCapture Antibody: Rabbit purified polyclonal anti-EPHA2Detection Antibody: Mouse polyclonal anti-EPHA2
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Antigen Detail | |
|---|---|
| Target | EPHA2 |
| Description | EphA2 is a principal receptor tyrosine kinase mediating blood-brain barrier breakdown during Plasmodium infection. TR4 may function as a suppressor of hepatocellular carcinoma metastasis by down-regulating the expression of EphA2. With ephrin-A2/EFNA2 may play a role in bone remodeling through regulation of osteoclastogenesis and osteoblastogenesis. |
| Species Reactivity | Human |
Capture Antibody | |
|---|---|
| Capture Clonality | Polyclonal |
| Host Species | Rabbit |
| Purification | Affinity chromatography |
| Buffer | PBS, pH 7.4, containing 0.1% Proclin 300 |
| Application | ELISA |
Detection Antibody | |
|---|---|
| Det-Clonality | Polyclonal |
| Host Species | Mouse |
| Conjugation | Unconjugated |
| Purification | Affinity chromatography |
| Buffer | PBS, pH 7.4 |
General Product Property | |
|---|---|
| Product Overview | Human EPHA2 Matched Antibody Pair set for ELISA use Capture Antibody: Rabbit purified polyclonal anti-EPHA2 Detection Antibody: Mouse polyclonal anti-EPHA2 |
| Specificity | Validated for detecting natural and recombinant human EPHA2 |
| Research Area | Receptor tyrosine kinase |
| Application | ELISA |
| Application Notes | Optimal dilutions should be determined experimentally by the user. |
| Form | Lyophilized |
| Storage | Avoid repeated freeze/thaw cycles. Store at 2-8°C for short term. Aliquot and store at -20°C for long term storage. |
| Size | 1 Set |
| Sample Type | Serum; Supernatant; Urine; Cell lysate; Plasma; Tissue Homogenates |
| Usage Statement | Available for Research Use Only. Not for use in therapeutic or diagnostic applications. |
Target Overview | |
|---|---|
| Gene Symbol | EPHA2 |
| Full Name | EPH receptor A2 (ephrin type-A receptor 2) |
| Background | EPH receptor A2 (ephrin A receptor 2) is a protein encoded by the EPHA2 gene in humans. This gene belongs to the ephrin receptor subfamily of the protein tyrosine kinase family. EPH and EPH-related receptors are involved in mediating developmental events, especially in the nervous system. The receptors in the EPH subfamily usually have a single kinase domain and an extracellular region, which contains a Cys-rich domain and two fibronectin type III repeats. ephrin receptors are divided into two categories based on the similarity of their extracellular domain sequences and their affinity for binding ephrin-A and ephrin-B ligands. This gene encodes a protein that binds ephrin-A ligand. |
| Alternative Names | EPHA2; Epha2; AW545284; Eck; Myk2; Sek-2; Sek2; ARCC2; CTPA; CTPP1; CTRCT6; EPH receptor A2; ECK |
| Gene ID | 1969 |
| Uniprot ID | P29317 |
| GeneCards | EPHA2 |
| HGNC | 3386 |
| Ensembl | ENSG00000142627 |
| OMIM | 176946 |
| Involvement in Disease | Diseases associated with EPHA2 include?Cataract 6, Multiple Types?and?Early-Onset Posterior Subcapsular Cataract. |
| Function | Receptor for members of the ephrin-A family. Binds to ephrin-A1, -A3, -A4 and -A5. Plays an important role in angiogenesis and tumor neovascularization. The recruitement of VAV2, VAV3 and PI3-kinase p85 subunit by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly (By similarity). Induces apoptosis in a p53/TP53-independent, caspase-8-dependent manner. |
| Related Pathways | Its related pathways are Guidance Cues and Growth Cone Motility and Activation of cAMP-Dependent PKA. |
For Research Use Only.
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