Human GGA1 Matched Antibody Pair set for ELISA useCapture Antibody: Mouse monoclonal anti-GGA1Detection Antibody: Rabbit purified polyclonal anti-GGA1
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Antigen Detail | |
|---|---|
| Target | GGA1 |
| Description | ADP-ribosylation factor-binding protein GGA1 is a protein that in humans is encoded by the GGA1 gene. GGA1 has been shown to interact with Sortilin 1, BACE2, RABEP1, and ARF3. |
| Species Reactivity | Human |
Capture Antibody | |
|---|---|
| Capture Clonality | Monoclonal |
| Host Species | Mouse |
| Clone | IV01746 |
| Purification | Affinity chromatography |
| Buffer | PBS, pH 7.4, containing 0.1% Proclin 300 |
| Application | ELISA |
Detection Antibody | |
|---|---|
| Det-Clonality | Polyclonal |
| Host Species | Rabbit |
| Conjugation | Unconjugated |
| Purification | Affinity chromatography |
| Buffer | PBS, pH 7.4 |
General Product Property | |
|---|---|
| Product Overview | Human GGA1 Matched Antibody Pair set for ELISA use Capture Antibody: Mouse monoclonal anti-GGA1 Detection Antibody: Rabbit purified polyclonal anti-GGA1 |
| Specificity | Validated for detecting natural and recombinant human GGA1 |
| Research Area | Protein Trafficking |
| Application | ELISA |
| Application Notes | Optimal dilutions should be determined experimentally by the user. |
| Form | Lyophilized |
| Storage | Avoid repeated freeze/thaw cycles. Store at 2-8°C for short term. Aliquot and store at -20°C for long term storage. |
| Size | 1 Set |
| Sample Type | Serum; Supernatant; Urine; Cell lysate; Plasma; Tissue Homogenates |
| Usage Statement | Available for Research Use Only. Not for use in therapeutic or diagnostic applications. |
Target Overview | |
|---|---|
| Gene Symbol | GGA1 |
| Full Name | Golgi Associated, Gamma Adaptin Ear Containing, ARF Binding Protein 1 |
| Background | This gene encodes a member of the Golgi-localized, gamma adaptin ear-containing, ARF-binding (GGA) protein family. Members of this family are ubiquitous coat proteins that regulate the trafficking of proteins between the trans-Golgi network and the lysosome. These proteins share an amino-terminal VHS domain which mediates sorting of the mannose 6-phosphate receptors at the trans-Golgi network. They also contain a carboxy-terminal region with homology to the ear domain of gamma-adaptins. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
| Alternative Names | ADP-Ribosylation Factor Binding Protein 1 |
| Gene ID | 26088 |
| Uniprot ID | Q9UJY5 |
| GeneCards | GGA1 |
| HGNC | 17842 |
| Ensembl | ENSG00000100083 |
| OMIM | 606004 |
| Involvement in Disease | Diseases associated with GGA1 include 3-Methylglutaconic Aciduria, Type Vii and 3-Methylglutaconic Aciduria, Type Iv. |
| Function | Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF-dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (DXXLL) motif (PubMed:11301005, PubMed:15886016). Mediates export of the GPCR receptor ADRA2B to the cell surface (PubMed:27901063). Required for targeting PKD1:PKD2 complex from the trans-Golgi network to the cilium membrane (By similarity). Regulates retrograde transport of proteins such as phosphorylated form of BACE1 from endosomes to the trans-Golgi network (PubMed:15886016, PubMed:15615712). |
| Related Pathways | Its related pathways are Vesicle-mediated transport and Metabolism of proteins. |
For Research Use Only.
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