Human GHRL antibody pair set for sandwich ELISA useCapture Antibody: Monoclonal IgGDetection Antibody: Unconjugated-Rabbit Monoclonal IgG
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Antigen Detail | |
|---|---|
| Target | GHRL |
| Description | Ghrelin is a circulating hormone produced by the intestinal endocrine cells of the gastrointestinal tract, especially the stomach, , and is often referred to as "hunger hormone" because it increases food intake. When hungry, the blood level of ghrelin before meals is the highest, and it drops to a lower level after meals. Growth hormone releasing peptide may help to prepare food intake by increasing gastric motility and gastric acid secretion . Ghrelin activates cells in the anterior pituitary and arcuate nucleus of the hypothalamus, [9] including neuropeptide Y neurons that cause appetite. Ghrelin stimulates the brain structure with specific receptors-growth hormone secretagogue receptor 1A (GHSR-1A). Ghrelin is also involved in the regulation of reward cognition, learning and memory, sleep-wake cycles, taste, reward behavior and glucose metabolism. |
| Species Reactivity | Human |
Capture Antibody | |
|---|---|
| Capture Clonality | Monoclonal |
| Host Species | Rabbit |
| Clone | IV01655 |
| Isotype | IgG |
| Purification | Affinity Chromatography |
| Buffer | PBS, pH 7.4, containing 0.1% Proclin 300 |
| Application | ELISA |
Detection Antibody | |
|---|---|
| Det-Clonality | Monoclonal |
| Host Species | Rabbit |
| Conjugation | Unconjugated |
| Clone | RD10402 |
| Isotype | IgG |
| Purification | Affinity Chromatography |
| Buffer | PBS, pH 7.4, BSA and Azide free |
General Product Property | |
|---|---|
| Product Overview | Human GHRL antibody pair set for sandwich ELISA use Capture Antibody: Monoclonal IgG Detection Antibody: Unconjugated-Rabbit Monoclonal IgG |
| Specificity | Both the capture and the detection antibodies in this set react with Human GHRL. |
| Research Area | Signal Transduction; Metabolism; Neuroscience |
| Application | ELISA |
| Application Notes | Optimal dilutions should be determined experimentally by the user. |
| Form | Liquid |
| Storage | Avoid repeated freeze/thaw cycles. Store at 2-8°C for short term. Aliquot and store at -20°C for long term storage. |
| Size | 1 Set |
| Sample Type | Plasma; Serum; Cell Culture Supernatant |
| Usage Statement | Available for Research Use Only. Not for use in therapeutic or diagnostic applications. |
Target Overview | |
|---|---|
| Gene Symbol | GHRL |
| Full Name | Ghrelin |
| Background | Ghrelin is a circulating hormone produced by the intestinal endocrine cells of the gastrointestinal tract, especially the stomach, , and is often referred to as "hunger hormone" because it increases food intake. When hungry, the blood level of ghrelin before meals is the highest, and it drops to a lower level after meals. Growth hormone releasing peptide may help to prepare food intake by increasing gastric motility and gastric acid secretion . Ghrelin activates cells in the anterior pituitary and arcuate nucleus of the hypothalamus, [9] including neuropeptide Y neurons that cause appetite. Ghrelin stimulates the brain structure with specific receptors-growth hormone secretagogue receptor 1A (GHSR-1A). Ghrelin is also involved in the regulation of reward cognition, learning and memory, sleep-wake cycles, taste, reward behavior and glucose metabolism. |
| Alternative Names | GHRL; MTLRP; ghrelin and obestatin prepropeptide; Ghrelin |
| GeneCards | GHRL |
| HGNC | 18129 |
| Ensembl | ENSG00000157017 |
| OMIM | 605353 |
| Involvement in Disease | Diseases associated with GHRL include Body Mass Index Quantitative Trait Locus 11 and Bulimia Nervosa. |
| Function | Ghrelin is the ligand for growth hormone secretagogue receptor type 1 (GHSR). Induces the release of growth hormone from the pituitary. Has an appetite-stimulating effect, induces adiposity and stimulates gastric acid secretion. Involved in growth regulation. Obestatin may be the ligand for GPR39. May have an appetite-reducing effect resulting in decreased food intake. May reduce gastric emptying activity and jejunal motility. |
For Research Use Only.
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