Monkey G-CSF antibody pair set for ELISA useCapture Antibody: Mouse Monoclonal IgG1Detection Antibody: Rabbit Monoclonal IgG
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Antigen Detail | |
|---|---|
| Target | G-CSF |
| Description | Granulocyte colony-stimulating factor (G-CSF or GCSF), also known as colony-stimulating factor 3 (CSF 3), is a glycoprotein that stimulates the bone marrow to produce granulocytes and stem cells and release them into the bloodstream. Functionally, it is a cytokine and hormone, a type of colony-stimulating factor, and is produced by a number of different tissues. The pharmaceutical analogs of naturally occurring G-CSF are called filgrastim and lenograstim. G-CSF also stimulates the survival, proliferation, differentiation, and function of neutrophil precursors and mature neutrophils. |
| Species Reactivity | Monkey |
Capture Antibody | |
|---|---|
| Capture Clonality | Monoclonal |
| Host Species | Mouse |
| Production | Cell culture |
| Clone | IV01767 |
| Isotype | IgG1 |
| Purification | DEAE ion exchange chromatography |
| Buffer | Prior to lyophilization: 0.25 ml PBS containing 125 mM trehalose |
| Application | ELISA |
Detection Antibody | |
|---|---|
| Det-Clonality | Polyclonal |
| Host Species | Rabbit |
| Conjugation | Biotin |
| Isotype | IgG |
| Purification | Ammonium sulphate precipitation and protein A-affinity chromatography |
| Buffer | Prior to lyophilization: 0.5 ml PBS containing 1% BSA and 125 mM trehalose |
General Product Property | |
|---|---|
| Product Overview | Monkey G-CSF antibody pair set for ELISA use Capture Antibody: Mouse Monoclonal IgG1 Detection Antibody: Rabbit Monoclonal IgG |
| Specificity | Validated for detecting natural rhesus macaque G-CSF. |
| Sensitivity | 2 pg/ml |
| Research Area | Immunology |
| Application | ELISA |
| Application Notes | Optimal dilutions should be determined experimentally by the user. |
| Form | Lyophilized |
| Storage | Avoid repeated freeze/thaw cycles. Store at 2-8°C for short term. Aliquot and store at -20°C for long term storage. |
| Size | 1 Set |
| Sample Type | Serum; Supernatant; Urine; Cell lysate; Plasma; Tissue Homogenates |
| Usage Statement | Available for Research Use Only. Not for use in therapeutic or diagnostic applications. |
Target Overview | |
|---|---|
| Gene Symbol | CSF3 |
| Full Name | Granulocyte colony-stimulating factor |
| Background | This gene encodes a member of the IL-6 superfamily of cytokines. The encoded cytokine controls the production, differentiation, and function of granulocytes. Granulocytes are a type of white blood cell that are part of the innate immune response. A modified form of this protein is commonly administered to manage chemotherapy-induced neutropenia. Alternatively spliced transcript variants have been described for this gene. |
| Alternative Names | CSF3; C17orf33; CSF3OS; GCSF; colony stimulating factor 3 |
| Gene ID | 1440 |
| Uniprot ID | P09919 |
| GeneCards | CSF3 |
| HGNC | 2438 |
| Ensembl | ENSG00000108342 |
| OMIM | 138970 |
| Involvement in Disease | Diseases associated with CSF3 include Neutropenia and Mucositis. |
| Function | Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. This CSF induces granulocytes. |
| Related Pathways | Its related pathways are PEDF Induced Signaling and Hematopoietic cell lineage. |
For Research Use Only.
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