Name: Mouse GM-CSF ELISA Matched Antibody Pair Set [ABP-Q-04-121]
SKU: ABP-Q-04-121
Price: 919.6 USD

Mouse GM-CSF ELISA Matched Antibody Pair Set [ABP-Q-04-121] (CAT#: ABP-Q-04-121)

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Mouse GM-CSF antibody pair set for ELISA useCapture Antibody: rabbit anti-Mouse GM-CSF monoclonal antibodyDetection Antibody: rabbit anti-Mouse GM-CSF polyclonal antibody conjugated to HRP

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Type	Size	Price	Quantity
Antibody Pair Set-Package 1	5 × 96 tests	$919.60
Antibody Pair Set-Package 2	15 × 96 tests	$1,919.66

Datasheet

MSDS

Certificate of Analysis Lookup

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Lot Number

Antigen Detail
Target	GM-CSF
Description	Granulocyte-macrophage colony-stimulating factor (GM-CSF) is one of an array of cytokines with pivotal roles in embryo implantation and subsequent development. Several cell lineages in the reproductive tract and gestational tissues synthesise GM-CSF under direction by ovarian steroid hormones and signalling agents originating in male seminal fluid and the conceptus. The pre-implantation embryo, invading placental trophoblast cells and the abundant populations of leukocytes controlling maternal immune tolerance are all subject to GM-CSF regulation. GM-CSF stimulates the differentiation of hematopoietic progenitors to monocytes and neutrophils, and reduces the risk for febrile neutropenia in cancer patients. GM-CSF also has been shown to induce the differentiation of myeloid dendritic cells (DCs) that promote the development of T-helper type 1 (cellular) immune responses in cognate T cells. The active form of the protein is found extracellularly as a homodimer, and the encoding gene is localized to a related gene cluster at chromosome region 5q31 which is known to be associated with 5q-syndrome and acute myelogenous leukemia. As a part of the immune/inflammatory cascade, GM-CSF promotes Th1 biased immune response, angiogenesis, allergic inflammation, and the development of autoimmunity, and thus worthy of consideration for therapeutic target. GM-CSF has been utilized in the clinical management of multiple disease processes. Most recently, GM-CSF has been incorporated into the treatment of malignancies as a sole therapy, as well as a vaccine adjuvant. While the benefits of GM-CSF in this arena have been promising, recent reports have suggested the potential for GM-CSF to induce immune suppression and, thus, negatively impact outcomes in the management of cancer patients. GM-CSF deficiency in pregnancy adversely impacts fetal and placental development, as well as progeny viability and growth after birth, highlighting this cytokine as a central maternal determinant of pregnancy outcome with clinical relevance in human fertility.
Species Reactivity	Mouse

Capture Antibody
Capture Clonality	Monoclonal
Host Species	Rabbit
Clone	IV01437
Purification	Affinity Chromatography
Buffer	Prior to lyophilization: PBS, pH 7.4
Application	ELISA

Detection Antibody
Det-Clonality	Polyclonal
Host Species	Rabbit
Conjugation	HRP
Purification	Affinity Chromatography
Buffer	Prior to lyophilization: PBS, containing 50 % HRP-Protector

General Product Property
Product Overview	Mouse GM-CSF antibody pair set for ELISA use Capture Antibody: rabbit anti-Mouse GM-CSF monoclonal antibody Detection Antibody: rabbit anti-Mouse GM-CSF polyclonal antibody conjugated to HRP
Specificity	Quantitative determination of Mouse GM-CSF
Range	1.88-120 pg/mL
Research Area	Innate Immunity
Application	ELISA
Application Notes	Optimal dilutions should be determined experimentally by the user.
Form	Lyophilized
Storage	Avoid repeated freeze/thaw cycles. Store at 2-8°C for short term. Aliquot and store at -20°C for long term storage.
Size	1 Set
Sample Type	Serum; Supernatant; Urine; Cell lysate; Plasma; Tissue Homogenates
Usage Statement	Available for Research Use Only. Not for use in therapeutic or diagnostic applications.

Target Overview
Gene Symbol	CSF2
Full Name	Granulocyte-macrophage colony-stimulating factor
Background	Granulocyte macrophage colony stimulating factor (GM-CSF), also known as colony stimulating factor 2 (CSF2), is a monomer secreted by macrophages, T cells, mast cells, natural killer cells, endothelial cells and fibroblasts Glycoprotein cytokine. Unlike granulocyte colony stimulating factor, which promotes the proliferation and maturation of neutrophils, GM-CSF affects more cell types, especially macrophages and eosinophils.
Alternative Names	CSF2, GMCSF, colony stimulating factor 2, CSF
Gene ID	1437(Human); 12981(Mouse)
Uniprot ID	P04141(Human); P01587(Mouse)

For Research Use Only.

Mouse GM-CSF ELISA Matched Antibody Pair Set [ABP-Q-04-121] (CAT#: ABP-Q-04-121)

Antigen Detail

Capture Antibody

Detection Antibody

General Product Property

Target Overview