Recently, fungus infection has become a serious problem across the world. As a leading company in the field of drug discovery, Creative Biolabs is capable of providing high-quality antifungal drug discovery services to help global customers exploit new drug candidates for the treatment of fungal disease. Now, we are happy to introduce our antifungal drug discovery service against sporothrix schenckii (S. schenckii).
Introduction of S. schenckii
S. schenckii is a fungus belonging to the kingdom Fungi and a eukaryotic organism without mobility and heterotrophic and presents chitin on its cell wall. It can be found worldwide in the environment, especially in soil associated with plant organic matter (for example, thorns, dry leaves, and wood), water, and decomposing organic matter, among others. Generally, this fungus is dimorphic with a mycelial phase and a yeast phase. The mycelial saprophytic phase is characterized by slender, hyaline, septate and branched hyphae containing thin conidiophores whose apex forms a small vesicle with sympodially arranged denticles. However, the yeast parasitic phase is pleomorphic, showing spindle-shaped and/or oval cells measuring 2.5 to 5 mm in diameter and resembling a ''cigar''.
Fig.1 Melanin ghosts of S. schenckii 18782 strain under several culture conditions. (de Lima Barros, 2011)
Pathogenesis of S. schenckii
S. schenckii is the causative agent of sporotrichosis which can infect humans as well as animals. Generally, infection results from inoculation of the fungus through thorns, splinters, scratches, and small traumas during leisure and occupational activities such as floriculture, horticulture, gardening, fishing, hunting, farming and cattle raising, mining, and wood exploration. Some certain leisure and occupational activities, such as floriculture, agriculture, mining, and wood exploitation, are traditionally associated with the mycosis.
Antifungal Drugs Against S. schenckii
In the past, different drug regimens have been developed for the treatment of S. schenckii infection. The choice is based on the individual's clinical condition, the extent of the cutaneous lesions, assessment of drug interactions and adverse events, and systemic involvement. Besides, discovering more effective antifungal drugs for the treatment of S. schenckii infection is also important.
Features of our Services
Working in the field for many years, Creative Biolabs has gained a wealth of experience and developed advanced technology platforms. We are able to provide a series of antifungal drug discovery services to meet every client’s requirements, which includes but not limited to target identification and validation, hit identification, and hit to lead. Furthermore, our high-quality services are characterized by:
Our experienced scientists are committed to promoting the development of global customers’ programs. If you are interested in the services we can offer, please feel free to contact us for more information.
Reference
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