5637 In Vitro Telomere Length Analysis Assay (Senescence) (CAT#: ITS-1022-YF2776)

5637

Human

Established from the primary bladder carcinoma (grade II) of a patient.

Urinary Bladder Cancer

Oncology

In Vitro Telomere Length Analysis Assay (Senescence)

5637-cell based In Vitro Telomere Length Analysis Assay (Senescence)

For the analysis of telomere length, terminal restriction fragment analysis technique has been the commonly used technique for a long time.

Cellular Senescence in Cancer Assays

Cell senescence is described as an irreversible physiological event of cell growth arrest, which is known to be caused by alterations of telomeres, oxidative stress, DNA damage and some oncogenes. Inhibition of the program of senescence is one of the main features of tumor cells and it has been reported that cancer cells can be induced to undergo senescence by chemo- and radiotherapies and genetic alterations. Telomeres help to prevent uncontrolled cell proliferation and the absence of telomeres results in aneuploidy and cell death.

Telomere Length Analysis Assay