DND-41 In Vitro ABTS Radical Cation Decolorization Assay (Oxidative Stress) (CAT#: ITS-1122-YF5223)

DND-41

Human

DND-41 was established from the peripheral blood of 13-year-old boy with T-acute lymphoblastic leukemia (T-ALL; type III cortical) in 1977; described to carry CDKN2B (p15INK4B) and CDKN2A (p16INK4A) deletions and TP53 (p53)mutation.

Acute Lymphoblastic Leukemia; ALL

Oncology

In Vitro ABTS Radical Cation Decolorization Assay (Oxidative Stress)

DND-41-cell based In Vitro ABTS Radical Cation Decolorization Assay (Oxidative Stress)

It's a commonly used simple antioxidant assay. The ability of antioxidants to reduce ABTS free radical (ABTS.) to ABTS is measured in the ABTS assay.

Oxidative Stress Assays

Disturbance between the production of reactive oxygen species (ROS), free radicals and antioxidant mechanisms is defined as the oxidative stress, or more precisely, it is an imbalance between the oxidant and antioxidant state in cells. This imbalance can cause harmful effects to cells and biomolecules, which ultimately causes adverse effects in the whole organism. Oxidative imbalance can target important proteinsand lipids in cells, which can increase the risk of developing a cancer. On the other hand, increased ROS production in cancer cells by certain cancer drugs can also arrest cancer cell cycle and cause senescence and apoptosis through oxidative stress.

Antioxidant Assay