GL261 In Vitro Genome Sequencing Assay (CAT#: ITS-1022-YF295)

GL261

Mouse

Glioma 261 (GL261) is a frequently used murine glioma model. It was induced via intracranial injection of methylcholanthrene followed by serial intracranial and subcutaneous transplantations of tumor fragments into syngeneic C57BL/6 mice. By the mid-1990s, multiple groups had established a permanent cell line from the tumor.

Glioma 261

Glioma

Oncology

In Vitro Genome Sequencing Assay

GL261-cell based In Vitro Genome Sequencing Assay

Genome sequencing is the most accurate and informative method used to identify gene mutations in basic biological and clinical research.

Genome Alteration Assays

Aberrant or somatic mutations are more commonly found in the DNA of cancer cells compared to normal cells. There is an equilibrium that exists between DNA damage and repair in normal cells. However, in cancer cells these events are disturbed, resulting in mutations and genomic instability. Genomic instability in cancer cells causes chromosomal aberrations, microsatellite instability, aneuploidy and uncontrolled gene amplifications and genetic instability in cancer cells are mainly due to point mutations or chromosomal aberrations such as insertions, deletions and translocation, resulting in mutated proteins.