High-Throughput Antibody Production Platform

Creative Biolabs is proud to offer a state-of-the-art High-Throughput (HTP) Antibody Production Platform, revolutionizing the field of antibody development. With over 20 years of experience in the industry, our company has been at the forefront of antibody research and development, consistently delivering innovative solutions to meet the evolving needs of our clients.

Highlights

Fast Delivery

Fast Delivery

HT recombinant antibody production services only take 18 working days from gene synthesis to antibody delivery.

Multiple Format

Multiple Format

HT antibody formats including full length antibody, Fabs, scFvs, VHHs, or other fragments fused with Fc

Multiple Format

High Throughput

A large capacity of 10,000+ targets/month and 100+ clones per session

Multiple Format

Excellent Quality

The purity of HT recombinant antibody is more than 95%

General Process

At Creative Biolabs, we have meticulously designed a comprehensive service process to ensure the successful generation of antibodies. The process involves several key steps:

HT Antibody Sequencing & Engineering

If an antibody with known sequence is available, we perform a sequence analysis to identify the variable regions (VH and VL) and the constant regions (CH and CL) of the antibody. If unknown, we perform HT sequencing service like:

  • High-Throughput Hybridoma Sequencing
  • High-Throughput de novo Monoclonal Antibody Sequencing
  • High-Throughput Polyclonal Antibody Sequencing
  • High-Throughput Single-cell BCR Sequencing (scBCR-seq)

HT Gene Synthesis & Vector Construction

We proceed gene synthesis and expression vectors with HT platform, including:

  • High-Throughput Silicon-based DNA Synthesis Platform
  • High-Throughput Vector Cloning Platform
  • High-Throughput Plasmid Preparation Platform

HT Stable Transfection

We perform stable transfection to introduce the expression vectors into the host cells. The choice of expression system depends on the specific requirements of the project.

  • High-Throughput DNA Plasmid Transfection Platform
  • High-Throughput CHO Antibody Prodcution Platform
  • High-Throughput HEK Antibody Prodcution Platform

HT Antibody Expression & Purification

Once the recombinant antibodies are produced, We use High-Throughput Antibody Purification Platform to obtain a highly pure and functional antibody preparation. The purification techniques include affinity chromatography, ion-exchange chromatography, size exclusion chromatography, and protein A/G purification.

HT Antibody Characterization

We conduct thorough characterization and quality control to ensure their quality and functionality. This includes:

  • High-Throughput SPR Platform for Antibody Affinity Characterization
  • High-Throughput ELISA Platform for Antibody Kinetics Characterization
  • High-Throughput Mass Spectrometry Platform for Antibody Developability Characterization
  • High-Throughput HPLC Platform for Antibody Developability Characterization

Service Specifications

Our High-Throughput Antibody Production Platform offers several key specifications that set it apart from traditional antibody production methods:

Service Name HTP (high throughput) Recombinant Antibody Production
Service Setup Gene synthesis and subclone, Transient expression and purification
Affinity purified antibody (up to mg level)
Service Description - Codon optimization and gene synthesis
- Subcloning into an expression vector
- Plasmid amplification and preparation
- Transient transfection of cells
- Antibody protein purification
QC - SDS-PAGE
- Endotoxin control
- LC-MS/HPLC
- Additional QC options available upon request with charge
Deliverables - Purified antibody (SDS-PAGE>95%, endotoxin level <1EU/mg, including SEC-HPLC detection)
- CoA report
Turnaround Time 2-3 weeks
Additional Services ELISA, FACS, SPR, Cell based assay, etc.

Creative Biolabs' High-Throughput Antibody Production Platform offers a comprehensive and efficient solution for antibody development. The platform's advanced technologies, streamlined processes, and customizable options enable rapid screening, characterization, and production of high-quality antibodies for various applications. With our experienced team and commitment to excellence, Creative Biolabs is your trusted partner in accelerating antibody discovery and development.

Please feel free to contact us for more about our HT antibody development services.

For Research Use Only | Not For Clinical Use

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