Linker and Payload Synthesis

As an end-to-end solution provider, Creative Biolabs offers a series of antibody-drug conjugation (ADC) services including ADC antibody screening, conjugation chemistry, linker and payload service, analytical characterization and validation, fill and finish and other antibody relevant services to help our clients get a promising ADC candidate. We aim to simplify the pathway to patients with comprehensive ADC solutions.

Antibody-drug conjugate (ADC) consists of a cytotoxic payload drug and a molecular linker which connects the antibody and the payload. The antibody plays the cargo role to deliver the cytotoxic payload to the target cell for a lethal strike (see Fig.1 for 3 approved ADCs). With extensive libraries of payloads and linkers, as well as extensive experience in synthetic and conjugation chemistry, Creative Biolabs is dedicated to helping our clients design and prepare specific linker and payload for ADC creation service.

Fig.1 Structure of FDA-approved ADCs: Mylotarg, Adcetris, and Kadcyla. (blue: linker, red: payload) (Tsuchikama, 2018)

The payload plays a critical functional role in the therapeutic efficacy of ADC. Creative Biolabs offers customized payload assembling service with drug-linker according to the chemistry of the payload and the linker, as well as the specificity of our clients’ project. Once assembling completed, payload-linker will be conjugated to the antibodies. To fit the requirements, we have developed an advanced technical platform based on our extensive experience in payload and linker chemistry. Our platform is customized into two separate modules, including linker module and payload module, facilitate the assembly.

We offer payload module covering various cytotoxins in the categories of:

• Microtubule toxins;
• DNA toxins;
• Transcription toxins;
• Nanocarriers;
• Protein toxins;
• Toxic enzymes/ADEPT;
• Inhibitors.

We offer linker module covering both linker design and synthesis based on different drug release mechanisms.

• pH-sensitive linkers;
• Disulfide linkers;
• Peptide linkers;
• β-glucuronide linkers;
• Non-cleavable linkers.

Our End-to-end Linker/Payload Solutions

Based on a large in-house library of payloads, linkers and advanced synthetic chemistry platform, Creative Biolabs offer one-stop solutions for our clients to meet your demand ultimately and save your time.

Fig.2 End-to-end linker and payload solutions.

Highlights

• Extensive experience and senior scientists;
• Advanced chemistry platform with experienced chemists;
• Comprehensive end-to-end payload-linker services.

Creative Biolabs is dedicated to being your most reliable partner to provide chemical synthesis and high-quality linker-payload services. We are committed to promoting the progress of your ADC discovery and development projects. Any questions, please feel free to contact us for more information and a detailed quote.

Reference

1. Tsuchikama, Kyoji, and Zhiqiang An. "Antibody-drug conjugates: recent advances in conjugation and linker chemistries." Protein & Cell 9.1 (2018): 33-46.

For Research Use Only | Not For Clinical Use

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