SW-620 In Vitro Post-translational Modifications Assay (CAT#: ITS-1122-YF829)

SW-620

Human

SW620 [SW-620] cells are isolated from the large intestine of a 51-year-old male Dukes C colorectal cancer patient. The cells can be used for cancer and toxicology research.

SW620

Colorectal Adenocarcinoma; Colon Cancer

Oncology

In Vitro Post-translational Modifications Assay

SW-620-cell based In Vitro Post-translational Modifications Assay

Immunoassays and mass spectrometry techniques are considered ideal techniques for the detection of post-translational modification. Both the genetic and epigenetic modifications have contributed to the initiation and progression of cancer.

Gene and Protein Expression Assays

Following transcription, primary transcript RNA is converted into mature RNA by post-transcriptional modifications. Post-transcriptional modification includes three major steps namely the addition of a 5'cap, addition of a 3'polyadenylation tail and RNA splicing. Stability of RNA has been considered as very important for gene expression and proteins at the post-transcriptional level.