Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsWith over a decade of experience in phage display technology, Creative Biolabs can provide a series of antibody or peptide libraries that are available for licensing or direct screening. These ready-to-use libraries are invaluable resources for isolating target-specific binders for various research, diagnostic or therapeutic applications.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
HighlightsIntroduction of KCNJ12
KCNJ12, also known as ATP-sensitive inward rectifier potassium channel 12, is encoded by KCNJ12 gene. It belongs to the multiple inwardly rectifying channels that contribute to the cardiac inward rectifier current (IK1), which plays a crucial role in establishing action potential waveform and excitability of neuronal and muscle tissues. KCNJ12 is mainly expressed in skeletal muscle, brain, heart, and kidney. Recent studies suggest that KCNJ12 variants are associated with various diseases, such as Smith-magenis syndrome and Leber congenital amaurosis 16.
| Basic Information of KCNJ12 | |
| Protein Name | ATP-sensitive inward rectifier potassium channel 12 |
| Gene Name | KCNJ12 |
| Aliases | IRK2, KCNJN1 |
| Organism | Homo sapiens (Human) |
| UniProt ID | Q14500 |
| Transmembrane Times | 2 |
| Length (aa) | 433 |
| Sequence | MTAASRANPYSIVSSEEDGLHLVTMSGANGFGNGKVHTRRRCRNRFVKKNGQCNIEFANMDEKSQRYLADMFTTCVDIRWRYMLLIFSLAFLASWLLFGIIFWVIAVAHGDLEPAEGRGRTPCVMQVHGFMAAFLFSIETQTTIGYGLRCVTEECPVAVFMVVAQSIVGCIIDSFMIGAIMAKMARPKKRAQTLLFSHNAVVALRDGKLCLMWRVGNLRKSHIVEAHVRAQLIKPRVTEEGEYIPLDQIDIDVGFDKGLDRIFLVSPITILHEIDEASPLFGISRQDLETDDFEIVVILEGMVEATAMTTQARSSYLANEILWGHRFEPVLFEEKNQYKIDYSHFHKTYEVPSTPRCSAKDLVENKFLLPSANSFCYENELAFLSRDEEDEADGDQDGRSRDGLSPQARHDFDRLQAGGGVLEQRPYRRESEI |
Function of KCNJ12 Membrane Protein
KCNJ12, as a member of the inward-rectifier potassium channel family, is responsible for many biological functions. Previous research has indicated that KCNJ12 could be involved in establishing action potential waveforms and excitability of nerve and muscle tissues. In addition, studies conducted on KCNJ12 demonstrate that its variants should be causes of familial dilated cardiomyopathy (DC) and biomarkers for the esophageal squamous cell carcinoma. It has been documented that KCNJ12 (p.Glu334del) genetic polymorphism is significantly associated with DC.
Fig.1 Structure of chicken Kcnj12/Kir2.2 membrane protein.
Application of KCNJ12 Membrane Protein in Literature
This article conducts a whole exome sequencing (WES) to identify the potential biomarker of esophageal squamous cell carcinoma in several patients who carry KCNJ12/KCNJ18 and GPRIN2 genes. The results suggest that some variants of these genes should be associated with ESCC.
Authors examine the genetic variants in family patients with dilated cardiomyopathy. The data reveal KCNJ12 (p.Glu334del) genetic polymorphism is significantly associated with DC.
Authors in this group conduct the whole genome and exome sequencing of several genes, include (KCNJ12, KCNJ17, and KCNJ18) in patients who suffer from Kir channels-caused disorders. The results show that Kir2.6_RRAI and QHEV isoforms play an important role in thyrotoxic periodic paralysis.
KCNJ12 Preparation Options
To obtain the soluble and functional target protein, the versatile Magic™ membrane protein production platform in Creative Biolabs enables many flexible options, from which you can always find a better match for your particular project. Aided by our versatile Magic™ anti-membrane protein antibody discovery platform, we also provide customized anti-KCNJ12 antibody development services.
As a forward-looking research institute as well as a leading custom service provider in the field of membrane protein, Creative Biolabs has won good reputation among our worldwide customers for successfully accomplishing numerous challenging projects including generation of many functional membrane proteins. Please feel free to contact us for more information.
All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
