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Magic™ Antibody Discovery - Cynomolgus Fc gamma RIII/CD16 (17-208) Membrane Protein, Partial, -His -Avi tag, [Biotin] (CAT#: MP1422F)

Datasheet
This membrane protein is Cynomolgus Fc gamma RIII/CD16 (17-208). It has been tested in SDS-PAGE, SPR, ELISA, BLI. We provide this protein to facilitate your membrane protein antibody discovery and development.

Product Specifications

  • Host Species
  • Cynomolgus
  • Target Protein
  • Fc gamma RIII/CD16
  • Protein Length
  • ECD
  • Molecular Weight
  • The protein has a calculated MW of 25.7 kDa. The protein migrates as 36-45 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
  • Sequence
  • AA Gly 17 - Gln 208 (Accession # Q8SPW2-1).

Product Description

  • Activity
  • Yes
  • Application
  • SDS-PAGE, SPR, ELISA, BLI
  • Expression Systems
  • HEK293
  • Tag
  • His tag at the C-terminus followed by an Avi tag
  • Protein Format
  • Soluble
  • Reconstitution
  • Please see Certificate of Analysis for specific instructions.
  • Endotoxin
  • <1.0 EU/μg by the LAL method
  • Purity
  • >95% as determined by SDS-PAGE
  • Buffer
  • Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally trehalose is added as protectant before lyophilization.

Target

  • Target Protein
  • Fc gamma RIII/CD16
  • Full Name
  • Fc-gamma RIII
  • Introduction
  • Fc gamma RIII/CD16 is a low/intermediate affinity activating receptor for polyvalent immune-complexed IgG. It is involved in phagocytosis, secretion of enzymes and inflammatory mediators, antibody-dependent cytotoxicity, and clearance of immune complexes. It is expressed on NK cells, T cells, monocytes, and macrophages. Mouse Fc gamma RIII/CD16 is encoded by a single gene and is expressed as a type I transmembrane protein on a variety of myeloid and lymphoid cells. It associates with Fc R gamma to deliver an activating signal upon ligand binding.
  • Alternative Names
  • CD16; FCGR3A; FcRIII; low affinity immunoglobulin gamma Fc region receptor III; Fc gamma RIIIa; Fc gamma receptor 3A; IgG Fc receptor III

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