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Magic™ Antibody Discovery - Cynomolgus IL-3 R alpha / CD123 (18-302) Membrane Protein, Partial, -His tag (CAT#: MP0366F)

Datasheet
This membrane protein is Cynomolgus IL-3 R alpha / CD123 (18-302). It has been tested in SDS-PAGE, SPR, BLI. We provide this protein to facilitate your membrane protein antibody discovery and development.

Product Specifications

  • Host Species
  • Cynomolgus
  • Target Protein
  • IL-3 R alpha / CD123
  • Protein Length
  • ECD
  • Molecular Weight
  • The protein has a calculated MW of 34.7 kDa. The protein migrates as 45-60 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
  • Sequence
  • AA Arg 18 - Arg 302 (Accession # G8F3K3-1).

Product Description

  • Activity
  • Yes
  • Application
  • SDS-PAGE, SPR, BLI
  • Expression Systems
  • HEK293
  • Tag
  • His tag at the C-terminus
  • Protein Format
  • Soluble
  • Reconstitution
  • Please see Certificate of Analysis for specific instructions.
  • Endotoxin
  • <1.0 EU/μg by the LAL method
  • Purity
  • >90% as determined by SDS-PAGE.
  • Buffer
  • Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally trehalose is added as protectant before lyophilization

Target

  • Target Protein
  • IL-3 R alpha / CD123
  • Full Name
  • interleukin-3 receptor subunit alpha-like
  • Introduction
  • The protein encoded by this gene is an interleukin 3 specific subunit of a heterodimeric cytokine receptor. The receptor is comprised of a ligand specific alpha subunit and a signal transducing beta subunit shared by the receptors for interleukin 3 (IL3), colony stimulating factor 2 (CSF2/GM-CSF), and interleukin 5 (IL5). The binding of this protein to IL3 depends on the beta subunit. The beta subunit is activated by the ligand binding, and is required for the biological activities of IL3. This gene and the gene encoding the colony stimulating factor 2 receptor alpha chain (CSF2RA) form a cytokine receptor gene cluster in a X-Y pseudoautosomal region on chromosomes X or Y. Alternatively spliced transcript variants encoding distinct isoforms have been found.
  • Alternative Names
  • interleukin-3 receptor subunit alpha-like

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