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Magic™ Antibody Discovery - Cynomolgus / Rhesus macaque B7-2 / CD86 (19-240) Membrane Protein, Partial, -His tag (CAT#: MP1025F)

Datasheet
This membrane protein is Cynomolgus / Rhesus macaque B7-2 / CD86 (19-240). It has been tested in SDS-PAGE, ELISA, SEC-HPLC. We provide this protein to facilitate your membrane protein antibody discovery and development.

Product Specifications

  • Host Species
  • Cynomolgus / Rhesus macaque
  • Target Protein
  • B7-2 / CD86
  • Protein Length
  • ECD
  • Molecular Weight
  • The protein has a calculated MW of 27.3 kDa. The protein migrates as 50-80 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
  • Sequence
  • AA Ala 19 - His 240 (Accession # G7NXR4-1).

Product Description

  • Activity
  • Yes
  • Application
  • SDS-PAGE, ELISA, SEC-HPLC
  • Expression Systems
  • HEK293
  • Tag
  • His tag at the C-terminus
  • Protein Format
  • Soluble
  • Reconstitution
  • Please see Certificate of Analysis for specific instructions.
  • Endotoxin
  • <1.0 EU/μg by the LAL method
  • Purity
  • >95% as determined by SDS-PAGE.
    >95% as determined by SEC-MALS.
  • Buffer
  • Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally trehalose is added as protectant before lyophilization.

Target

  • Target Protein
  • B7-2 / CD86
  • Full Name
  • CD86 molecule
  • Introduction
  • Receptor involved in the costimulatory signal essential for T-lymphocyte proliferation and interleukin-2 production, by binding CD28 or CTLA-4. May play a critical role in the early events of T-cell activation and costimulation of naive T-cells, such as deciding between immunity and anergy that is made by T-cells within 24 hours after activation. Also involved in the regulation of B cells function, plays a role in regulating the level of IgG1 produced. Upon CD40 engagement, activates NF-kappa-B signaling pathway via phospholipase C and protein kinase C activation (PubMed:23241883).
  • Alternative Names
  • T-lymphocyte activation antigen CD86, activation B7-2 antigen, early T cell costimulatory molecule-1

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