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Magic™ Antibody Discovery - Cynomolgus / Rhesus macaque PD-L1 / B7-H1 Membrane Protein, Partial, -His tag (CAT#: MP1468F)

Datasheet
This membrane protein is Cynomolgus / Rhesus macaque PD-L1 / B7-H1 (19-238). It has been tested in SDS-PGAE, ELISA, SPR, BLI. We provide this protein to facilitate your membrane protein antibody discovery and development.

Product Specifications

  • Host Species
  • Cynomolgus / Rhesus macaque
  • Target Protein
  • PD-L1 / B7-H1
  • Protein Length
  • ECD
  • Molecular Weight
  • The protein has a calculated MW of 27.1 kDa. The protein migrates as 37-42 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
  • Sequence
  • AA Phe 19 - Arg 238 (Accession # G7PSE7-1)

Product Description

  • Activity
  • Yes
  • Application
  • SDS-PGAE, ELISA, SPR, BLI
  • Expression Systems
  • HEK293
  • Tag
  • His Tag at the C-terminus
  • Protein Format
  • Soluble
  • Reconstitution
  • Please see Certificate of Analysis for specific instructions.
  • Endotoxin
  • <1.0 EU/μg by the LAL method
  • Purity
  • >95% as determined by SDS-PAGE
  • Buffer
  • Lyophilized from 0.22 μm filtered solution in PBS (pH7.4). Trehalose is added as protectant before lyophilization.

    Please contact us for customized formulation or product form if needed.

Target

  • Target Protein
  • PD-L1 / B7-H1
  • Introduction
  • The protein encoded by this gene is an immune inhibitory receptor ligand that is expressed by hematopoietic and non-hematopoietic cells, such as T cells and B cells and various types of tumor cells. The encoded protein is a type I transmembrane protein that has immunoglobulin V-like and C-like domains. Interaction of this ligand with its receptor inhibits T-cell activation and cytokine production. During infection or inflammation of normal tissue, this interaction is important for preventing autoimmunity by maintaining homeostasis of the immune response. In tumor microenvironments, this interaction provides an immune escape for tumor cells through cytotoxic T-cell inactivation. Mice deficient for this gene display a variety of phenotypes including decreased allogeneic fetal survival rates and severe experimental autoimmune encephalomyelitis.
  • Alternative Names
  • CD274, CD274 molecule, B7-H, B7H1, PDL1, PD-L1, hPD-L1, PDCD1L1, PDCD1LG1, B7-H1, programmed cell death 1 ligand 1, B7 homolog 1, CD274 antigen, PDCD1 ligand 1, Programmed death ligand 1, hPD-L1

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