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Magic™ Antibody Discovery - Human ADAM8 / CD156a (17-497) Membrane Protein, Partial, -His tag (CAT#: MP0938F)

Datasheet
This membrane protein is Human ADAM8 / CD156a (.). It has been tested in SDS-PAGE. We provide this protein to facilitate your membrane protein antibody discovery and development.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • ADAM8 / CD156a
  • Protein Length
  • ECD
  • Molecular Weight
  • Human ADAM8, His Tag fused with a polyhistidine tag at the C-terminus, has a calculated MW of 53.8 kDa, which migrates as a 180-220 kDa band in DTT-reduced SDS-PAGE due to glycosylation. Two main fragments bands are visible with apparent MW of 69-73 kDa and 46-48 kDa respectively in reduced SDS-PAGE as a result of its being prone to proteolytic cleavage.
  • Sequence
  • AA Ile 17 - Pro 497 (Accession # AAI15405.1).

Product Description

  • Application
  • SDS-PAGE
  • Expression Systems
  • HEK293
  • Tag
  • His tag at the C-terminus
  • Protein Format
  • Soluble
  • Reconstitution
  • Please see Certificate of Analysis for specific instructions.
  • Endotoxin
  • <1.0 EU/μg by the LAL method
  • Purity
  • >85% as determined by SDS-PAGE.
  • Buffer
  • Lyophilized from 0.22 μm filtered solution in 50 mM Tris, 150 mM NaCl, pH7.5. Normally trehalose is added as protectant before lyophilization.

Target

  • Target Protein
  • ADAM8 / CD156a
  • Full Name
  • ADAM metallopeptidase domain 8
  • Introduction
  • This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene may be involved in cell adhesion during neurodegeneration, and it is thought to be a target for allergic respiratory diseases, including asthma. Alternative splicing results in multiple transcript variants.
  • Alternative Names
  • MS2; CD156; CD156a; disintegrin and metalloproteinase domain-containing protein 8; a disintegrin and metalloproteinase domain 8; cell surface antigen MS2; human leukocyte differentiation antigen

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