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Magic™ Antibody Discovery - Human B7-2 / CD86 (26-247) Membrane Protein, Partial, -hIgG1 Fc tag (CAT#: MP1027F)

Datasheet
This membrane protein is Human B7-2 / CD86 (26-247). It has been tested in SDS-PAGE, FACS, ELISA, BLI, SPR. We provide this protein to facilitate your membrane protein antibody discovery and development.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • B7-2 / CD86
  • Protein Length
  • ECD
  • Molecular Weight
  • The protein has a calculated MW of 51.5 kDa. As a result of glycosylation, the protein migrates as 66-86 kDa under reducing (R) condition, and 120-140 kDa under non-reducing (NR) condition (SDS-PAGE).
  • Sequence
  • AA Leu 26 - Pro 247 (Accession # AAH40261).

Product Description

  • Activity
  • Yes
  • Application
  • SDS-PAGE, FACS, ELISA, BLI, SPR
  • Expression Systems
  • HEK293
  • Tag
  • Human IgG1 Fc tag at the C-terminus
  • Protein Format
  • Soluble
  • Reconstitution
  • Please see Certificate of Analysis for specific instructions.
  • Endotoxin
  • <1.0 EU/μg by the LAL method
  • Purity
  • >95% as determined by SDS-PAGE.
  • Buffer
  • Lyophilized from 0.22 μm filtered solution in Tris with Glycine, Arginine and NaCl, pH7.5. Normally trehalose is added as protectant before lyophilization.

Target

  • Target Protein
  • B7-2 / CD86
  • Full Name
  • CD86 molecule
  • Introduction
  • This gene encodes a type I membrane protein that is a member of the immunoglobulin superfamily. This protein is expressed by antigen-presenting cells, and it is the ligand for two proteins at the cell surface of T cells, CD28 antigen and cytotoxic T-lymphocyte-associated protein 4. Binding of this protein with CD28 antigen is a costimulatory signal for activation of the T-cell. Binding of this protein with cytotoxic T-lymphocyte-associated protein 4 negatively regulates T-cell activation and diminishes the immune response. Alternative splicing results in several transcript variants encoding different isoforms.
  • Alternative Names
  • B70; B7-2; B7.2; LAB72; CD28LG2; T-lymphocyte activation antigen CD86; B-lymphocyte activation antigen B7-2; BU63; CD86 antigen (CD28 antigen ligand 2, B7-2 antigen); CTLA-4 counter-receptor B7.2; FUN-1

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