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Magic™ Antibody Discovery - Human C-Reactive (19-224) Membrane Protein, Partial, -His tag (CAT#: MP1182F)

Datasheet
This membrane protein is Human C-Reactive (19-224). It has been tested in SDS-PAGE. We provide this protein to facilitate your membrane protein antibody discovery and development.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • C-Reactive
  • Protein Length
  • ECD
  • Molecular Weight
  • The protein has a calculated MW of 23.9 kDa. The protein migrates as 26 kDa under reducing (R) condition (SDS-PAGE).
  • Sequence
  • AA Gln 19 - Pro 224 (Accession # NP_000558.2).

Product Description

  • Application
  • SDS-PAGE
  • Expression Systems
  • HEK293
  • Tag
  • His tag at the C-terminus
  • Protein Format
  • Soluble
  • Reconstitution
  • Please see Certificate of Analysis for specific instructions.
  • Endotoxin
  • <1.0 EU/μg by the LAL method
  • Purity
  • >95% as determined by SDS-PAGE.
  • Buffer
  • Lyophilized from 0.22 μm filtered solution in Tris-NaCl buffer pH8.0. Normally trehalose is added as protectant before lyophilization.

Target

  • Target Protein
  • C-Reactive
  • Full Name
  • C-reactive protein
  • Introduction
  • The protein encoded by this gene belongs to the pentraxin family which also includes serum amyloid P component protein and pentraxin 3. Pentraxins are involved in complement activation and amplification via communication with complement initiation pattern recognition molecules, but also complement regulation via recruitment of complement regulators. The encoded protein has a calcium dependent ligand binding domain with a distinctive flattened beta-jellyroll structure. It exists in two forms as either a pentamer in circulation or as a nonsoluble monomer in tissues. It is involved in several host defense related functions based on its ability to recognize foreign pathogens and damaged cells of the host and to initiate their elimination by interacting with humoral and cellular effector systems in the blood. Consequently, the level of this protein in plasma increases greatly during acute phase response to tissue injury, infection, or other inflammatory stimuli. Elevated expression of the encoded protein is associated with severe acute respiratory syndrome coronavirus 2
  • Alternative Names
  • PTX1; C-reactive protein; C-reactive protein, pentraxin-related; pentraxin 1

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