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Magic™ Antibody Discovery - Human Cathepsin S / CTSS (17-331) Membrane Protein, Partial, -His tag (CAT#: MP1085F)

Datasheet
This membrane protein is Human Cathepsin S / CTSS (17-331). It has been tested in SDS-PAGE. We provide this protein to facilitate your membrane protein antibody discovery and development.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • Cathepsin S / CTSS
  • Protein Length
  • ECD
  • Molecular Weight
  • The protein has a calculated MW of 24.9 kDa. The protein migrates as 36-42 kDa (pro) and 26 kDa (mature) under reducing (R) condition (SDS-PAGE) due to glycosylation.
  • Sequence
  • AA Gln 17 - Ile 331 (Accession # P25774-1).

Product Description

  • Application
  • SDS-PAGE
  • Expression Systems
  • HEK293
  • Tag
  • His tag at the C-terminus
  • Protein Format
  • Soluble
  • Reconstitution
  • Please see Certificate of Analysis for specific instructions.
  • Endotoxin
  • <1.0 EU/μg by the LAL method
  • Purity
  • >95% as determined by SDS-PAGE.
  • Buffer
  • Lyophilized from 0.22 μm filtered solution in 50 mM MES, 100 mM NaCl, pH6.5. Normally trehalose is added as protectant before lyophilization.

Target

  • Target Protein
  • Cathepsin S / CTSS
  • Full Name
  • cathepsin S
  • Introduction
  • The preproprotein encoded by this gene, a member of the peptidase C1 family, is a lysosomal cysteine proteinase that participates in the degradation of antigenic proteins to peptides for presentation on MHC class II molecules. The mature protein cleaves the invariant chain of MHC class II molecules in endolysosomal compartments and enables the formation of antigen-MHC class II complexes and the proper display of extracellular antigenic peptides by MHC-II. The mature protein also functions as an elastase over a broad pH range. When secreted from cells, this protein can remodel components of the extracellular matrix such as elastin, collagen, and fibronectin. This gene is implicated in the pathology of many inflammatory and autoimmune diseases and, given its elastase activity, plays a significant role in some pulmonary diseases. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
  • Alternative Names
  • CTSS, cathepsin S, MGC3886, FLJ50259,

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