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Magic™ Antibody Discovery - Human CD27 / TNFRSF7 (21-192) Membrane Protein, Partial, -hIgG1 Fc tag (CAT#: MP1101F)

Datasheet
This membrane protein is Human CD27 / TNFRSF7 (21-192). It has been tested in SDS-PAGE, ELISA, Cell based assay. We provide this protein to facilitate your membrane protein antibody discovery and development.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • CD27 / TNFRSF7
  • Protein Length
  • ECD
  • Molecular Weight
  • The protein has a calculated MW of 45.9 kDa. The protein migrates as 53-66 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
  • Sequence
  • AA Thr 21 - Ile 192 (Accession # NP_001233).

Product Description

  • Activity
  • Yes
  • Application
  • SDS-PAGE, ELISA, Cell based assay
  • Expression Systems
  • HEK293
  • Tag
  • Human IgG1 Fc tag at the C-terminus
  • Protein Format
  • Soluble
  • Reconstitution
  • Please see Certificate of Analysis for specific instructions.
  • Endotoxin
  • <1.0 EU/μg by the LAL method
  • Purity
  • >95% as determined by SDS-PAGE.
  • Buffer
  • Lyophilized from 0.22 μm filtered solution in 50 mM Tris, 100 mM Glycine, pH7.5. Normally trehalose is added as protectant before lyophilization.

Target

  • Target Protein
  • CD27 / TNFRSF7
  • Full Name
  • CD27 molecule
  • Introduction
  • The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is required for generation and long-term maintenance of T cell immunity. It binds to ligand CD70, and plays a key role in regulating B-cell activation and immunoglobulin synthesis. This receptor transduces signals that lead to the activation of NF-kappaB and MAPK8/JNK. Adaptor proteins TRAF2 and TRAF5 have been shown to mediate the signaling process of this receptor. CD27-binding protein (SIVA), a proapoptotic protein, can bind to this receptor and is thought to play an important role in the apoptosis induced by this receptor.
  • Alternative Names
  • CD27, CD27 molecule, TNFRSF7, tumor necrosis factor receptor superfamily, member 7, CD27 antigen, S152, Tp55, CD27L receptor, T cell activation antigen S152, T-cell activation antigen CD27, tumor necrosis factor receptor superfamily, member 7, T14, TNFRSF7, MGC20393,

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