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Magic™ Antibody Discovery - Human CD3 epsilon&CD3 delta Heterodimer (23-126(CD3E)&22-105(CD3D)) Membrane Protein, Partial, -His-Avi & Free tag, [Biotin] (CAT#: MP1249F)

Datasheet
This membrane protein is Human CD3 epsilon&CD3 delta Heterodimer (23-126(CD3E)&22-105(CD3D)). It has been tested in SDS-PAGE, SEC-SEC-MALS, ELISA, SPR. We provide this protein to facilitate your membrane protein antibody discovery and development.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • CD3 epsilon&CD3 delta Heterodimer
  • Protein Length
  • ECD
  • Molecular Weight
  • Biotinylated Human CD3E&CD3D Heterodimer Protein, His,Avitag&Tag Free is produced by co-expression of CD3E and CD3D, has a calculated MW of 18.6 kDa (CD3E) and 13.4 kDa (CD3D). Subunit CD3E is fused with a polyhistidine tag and an Avi tag at the C-terminus and subunit CD3D contains no tag. As a result of glycosylation, the heterodimer protein migrates as 20-28 kDa under reducing (R) condition, and 38-47 kDa under non-reducing (NR) condition (SDS-PAGE).
  • Sequence
  • AA Asp 23 - Asp 126 (CD3E) & Phe 22 - Ala 105 (CD3D) (Accession # P07766-1(CD3E) & P04234-1(CD3D)).

Product Description

  • Activity
  • Yes
  • Application
  • SDS-PAGE, SEC-SEC-MALS, ELISA, SPR
  • Expression Systems
  • HEK293
  • Tag
  • CD3E subunit contains C terminal His and Avi tag. No tag for CD3D subunit.
  • Protein Format
  • Soluble
  • Reconstitution
  • Please see Certificate of Analysis for specific instructions.
  • Endotoxin
  • <0.1 EU/μg by the LAL method
  • Conjugation
  • Biotin
  • Purity
  • >90% as determined by SDS-PAGE.
  • Buffer
  • Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally trehalose is added as protectant before lyophilization.

Target

  • Target Protein
  • CD3 epsilon&CD3 delta Heterodimer
  • Full Name
  • CD3e molecule&CD3d molecule
  • Introduction
  • The protein encoded by this gene is the CD3-epsilon polypeptide, which together with CD3-gamma, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T-cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an essential role in T-cell development. Defects in this gene cause immunodeficiency. This gene has also been linked to a susceptibility to type I diabetes in women.
  • Alternative Names
  • CD3-epsilon, CD3e antigen, epsilon polypeptide (TiT3 complex), CD3e molecule, epsilon (CD3-TCR complex), T-cell antigen receptor complex, epsilon subunit of T3, T-cell surface antigen T3/Leu-4 epsilon chain, T-cell surface glycoprotein CD3 delta chain, CD3d molecule, delta (CD3-TCR complex)

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