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Magic™ Antibody Discovery - Human CD30 Ligand / TNFSF8 (63-234) Membrane Protein, Partial, mIgG2a Fc- tag, low endotoxin (CAT#: MP1204F)

Datasheet
This membrane protein is Human CD30 Ligand / TNFSF8 (63-234). It has been tested in SDS-PAGE, ELISA, BLI, FACS. We provide this protein to facilitate your membrane protein antibody discovery and development.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • CD30 Ligand / TNFSF8
  • Protein Length
  • ECD
  • Molecular Weight
  • The protein has a calculated MW of 46.5 kDa. The protein migrates as 55-66 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
  • Sequence
  • AA Gln 63 - Asp 234 (Accession # P32971-1).

Product Description

  • Activity
  • Yes
  • Application
  • SDS-PAGE, ELISA, BLI, FACS
  • Expression Systems
  • HEK293
  • Tag
  • Mouse IgG2a Fc tag at the N-terminus
  • Protein Format
  • Soluble
  • Reconstitution
  • Please see Certificate of Analysis for specific instructions.
  • Endotoxin
  • <0.1 EU/μg by the LAL method
  • Purity
  • >95% as determined by SDS-PAGE.
  • Buffer
  • Lyophilized from 0.22 μm filtered solution in Tris with Glycine, Arginine and NaCl, pH7.5. Normally trehalose is added as protectant before lyophilization.

Target

  • Target Protein
  • CD30 Ligand / TNFSF8
  • Full Name
  • TNF superfamily member 8
  • Introduction
  • The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF8/CD30, which is a cell surface antigen and a marker for Hodgkin lymphoma and related hematologic malignancies. The engagement of this cytokine expressed on B cell surface plays an inhibitory role in modulating Ig class switch. This cytokine was shown to enhance cell proliferation of some lymphoma cell lines, while to induce cell death and reduce cell proliferation of other lymphoma cell lines. The pleiotropic biologic activities of this cytokine on different CD30+ lymphoma cell lines may play a pathophysiologic role in Hodgkin's and some non-Hodgkin's lymphomas. Two transcript variants encoding different isoforms have been found for this gene.
  • Alternative Names
  • CD153; CD30L; CD30LG; TNLG3A; tumor necrosis factor ligand superfamily member 8; CD153 antigen; CD30 antigen ligand; CD30 ligand; CD30-L; tumor necrosis factor (ligand) superfamily, member 8; tumor necrosis factor ligand 3A; tumor necrosis factor superfamily member 8

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