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Magic™ Antibody Discovery - Human Coagulation factor XI / FXI (19-625) Membrane Protein, Partial, -His tag (CAT#: MP1086F)

Datasheet
This membrane protein is Human Coagulation factor XI / FXI (19-625). It has been tested in SDS-PAGE. We provide this protein to facilitate your membrane protein antibody discovery and development.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • Coagulation factor XI / FXI
  • Protein Length
  • ECD
  • Molecular Weight
  • The proprotein is activated by factor XIIa (or XII) and cleaved after Arg-387 into the light chain with calculated MW of 28.7 kDa, which contains the active site, and the heavy chain with calculated MW of 41.2 kDa. The protein migrates as 47 kDa (heavy chain) and 35 kDa (light chain) under reducing (R) condition (SDS-PAGE) due to glycosylation.
  • Sequence
  • AA Glu 19 - Val 625 (Accession # P03951-1).

Product Description

  • Application
  • SDS-PAGE
  • Expression Systems
  • HEK293
  • Tag
  • His tag at the C-terminus
  • Protein Format
  • Soluble
  • Reconstitution
  • Please see Certificate of Analysis for specific instructions.
  • Endotoxin
  • <1.0 EU/μg by the LAL method
  • Purity
  • >90% as determined by SDS-PAGE.
  • Buffer
  • Lyophilized from 0.22 μm filtered solution in 25 mM HEPES, 150 mM NaCl, pH7.5. Normally trehalose is added as protectant before lyophilization.

Target

  • Target Protein
  • Coagulation factor XI / FXI
  • Full Name
  • coagulation factor XI
  • Introduction
  • This gene encodes coagulation factor XI of the blood coagulation cascade. This protein is present in plasma as a zymogen, which is a unique plasma coagulation enzyme because it exists as a homodimer consisting of two identical polypeptide chains linked by disulfide bonds. During activation of the plasma factor XI, an internal peptide bond is cleaved by factor XIIa (or XII) in each of the two chains, resulting in activated factor XIa, a serine protease composed of two heavy and two light chains held together by disulfide bonds. This activated plasma factor XI triggers the middle phase of the intrisic pathway of blood coagulation by activating factor IX. Defects in this factor lead to Rosenthal syndrome, a blood coagulation abnormality.
  • Alternative Names
  • FXI; PTA; coagulation factor XI; plasma thromboplastin antecedent

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