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Magic™ Antibody Discovery - Human Dkk-1 (32-266) Membrane Protein, Partial, -hIgG1 Fc tag (CAT#: MP1363F)

Datasheet
This membrane protein is Human Dkk-1 (32-266). It has been tested in SDS-PAGE. We provide this protein to facilitate your membrane protein antibody discovery and development.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • Dkk-1
  • Protein Length
  • ECD
  • Molecular Weight
  • The protein has a calculated MW of 52.4 kDa. The protein migrates as 67-85 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
  • Sequence
  • AA Thr 32 - His 266 (Accession # NP_036374.1).

Product Description

  • Application
  • SDS-PAGE
  • Expression Systems
  • HEK293
  • Tag
  • Human IgG1 Fc tag at the C-terminus
  • Protein Format
  • Soluble
  • Reconstitution
  • Please see Certificate of Analysis for specific instructions.
  • Endotoxin
  • <1.0 EU/μg by the LAL method
  • Purity
  • >95% as determined by SDS-PAGE.
  • Buffer
  • Lyophilized from 0.22 μm filtered solution in Tris with Glycine, Arginine and NaCl, pH7.5. Normally trehalose is added as protectant before lyophilization.

Target

  • Target Protein
  • Dkk-1
  • Full Name
  • dickkopf WNT signaling pathway inhibitor 1
  • Introduction
  • This gene encodes a member of the dickkopf family of proteins. Members of this family are secreted proteins characterized by two cysteine-rich domains that mediate protein-protein interactions. The encoded protein binds to the LRP6 co-receptor and inhibits beta-catenin-dependent Wnt signaling. This gene plays a role in embryonic development and may be important in bone formation in adults. Elevated expression of this gene has been observed in numerous human cancers and this protein may promote proliferation, invasion and growth in cancer cell lines.
  • Alternative Names
  • SK; DKK-1; dickkopf-related protein 1; dickkopf 1 homolog; dickkopf-1 like; dickkopf-like protein 1

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