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Magic™ Antibody Discovery - Human E-Cadherin / Cadherin-1 (23-621) Membrane Protein, Partial, -hIgG1 Fc tag (CAT#: MP1398F)

Datasheet
This membrane protein is Human E-Cadherin / Cadherin-1 (23-621). It has been tested in SDS-PAGE. We provide this protein to facilitate your membrane protein antibody discovery and development.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • E-Cadherin / Cadherin-1
  • Protein Length
  • ECD
  • Molecular Weight
  • The protein has a calculated MW of 92.3 kDa. The protein migrates as 100 kDa and 120 kDa Cadherin, a 48 kDa Propeptide under reducing (R) condition (SDS-PAGE) due to different glycosylation.
  • Sequence
  • AA Gln 23 - Pro 621 (Accession # AAI41839).

Product Description

  • Application
  • SDS-PAGE
  • Expression Systems
  • HEK293
  • Tag
  • Human IgG1 Fc tag at the C-terminus
  • Protein Format
  • Soluble
  • Reconstitution
  • Please see Certificate of Analysis for specific instructions.
  • Endotoxin
  • <1.0 EU/μg by the LAL method
  • Purity
  • >95% as determined by SDS-PAGE.
  • Buffer
  • Lyophilized from 0.22 μm filtered solution in 50 mM Tris, 100 mM Glycine, pH7.5. Normally trehalose is added as protectant before lyophilization.

Target

  • Target Protein
  • E-Cadherin / Cadherin-1
  • Full Name
  • cadherin 1
  • Introduction
  • This gene encodes a classical cadherin of the cadherin superfamily. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature glycoprotein. This calcium-dependent cell-cell adhesion protein is comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function of this gene is thought to contribute to cancer progression by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. This gene is present in a gene cluster with other members of the cadherin family on chromosome 16.
  • Alternative Names
  • UVO; CDHE; ECAD; LCAM; Arc-1; BCDS1; CD324; cadherin-1; CAM 120/80; E-cadherin 1; cadherin 1, E-cadherin (epithelial); cadherin 1, type 1, E-cadherin (epithelial); calcium-dependent adhesion protein, epithelial; cell-CAM 120/80; epididymis secretory sperm binding protein; epithelial cadherin; uvomorulin

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