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Magic™ Antibody Discovery - Human Erythropoietin R / EPO R (25-241) Membrane Protein, Partial, -hIgG1 Fc tag (CAT#: MP1393F)

Datasheet
This membrane protein is Human Erythropoietin R / EPO R (25-241). It has been tested in SDS-PAGE. We provide this protein to facilitate your membrane protein antibody discovery and development.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • Erythropoietin R / EPO R
  • Protein Length
  • ECD
  • Molecular Weight
  • The protein has a calculated MW of 50.1 kDa.
  • Sequence
  • AA Ala 25 - Cys 241 (Accession # P19235-2).

Product Description

  • Application
  • SDS-PAGE
  • Expression Systems
  • HEK293
  • Tag
  • Human IgG1 Fc tag at the C-terminus
  • Protein Format
  • Soluble
  • Reconstitution
  • Please see Certificate of Analysis for specific instructions.
  • Buffer
  • Lyophilized from 0.22 μm filtered solution in 50 mM Tris, 100 mM Glycine, pH7.5. Normally trehalose is added as protectant before lyophilization.

Target

  • Target Protein
  • Erythropoietin R / EPO R
  • Full Name
  • erythropoietin receptor
  • Introduction
  • This gene encodes the erythropoietin receptor which is a member of the cytokine receptor family. Upon erythropoietin binding, this receptor activates Jak2 tyrosine kinase which activates different intracellular pathways including: Ras/MAP kinase, phosphatidylinositol 3-kinase and STAT transcription factors. The stimulated erythropoietin receptor appears to have a role in erythroid cell survival. Defects in the erythropoietin receptor may produce erythroleukemia and familial erythrocytosis. Dysregulation of this gene may affect the growth of certain tumors. Alternate splicing results in multiple transcript variants.
  • Alternative Names
  • EPO-R; erythropoietin receptor; truncated erythropoietin receptor

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