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Magic™ Antibody Discovery - Human FKBP12 / FKBP1A (1-108) Membrane Protein, Partial, -His tag (CAT#: MP0115F)

Datasheet
This membrane protein is Human FKBP12 / FKBP1A (1-108). It has been tested in SDS-PAGE. We provide this protein to facilitate your membrane protein antibody discovery and development.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • FKBP12 / FKBP1A
  • Protein Length
  • ECD
  • Molecular Weight
  • The protein has a calculated MW of 12.8 kDa. The protein migrates as 13 kDa under reducing (R) condition (SDS-PAGE).
  • Sequence
  • AA Met 1 - Glu 108 (Accession # P62942-1).

Product Description

  • Application
  • SDS-PAGE
  • Expression Systems
  • E.coli
  • Tag
  • His tag at the C-terminus
  • Protein Format
  • Soluble
  • Reconstitution
  • Please see Certificate of Analysis for specific instructions.
  • Endotoxin
  • <1.0 EU/μg by the LAL method
  • Purity
  • >95% as determined by SDS-PAGE.
  • Buffer
  • Lyophilized from 0.22 μm filtered solution in 50 mM HEPES, 150 mM NaCl, pH7.5. Normally trehalose is added as protectant before lyophilization.

Target

  • Target Protein
  • FKBP12 / FKBP1A
  • Full Name
  • FKBP prolyl isomerase 1A
  • Introduction
  • The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. The protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin. It interacts with several intracellular signal transduction proteins including type I TGF-beta receptor. It also interacts with multiple intracellular calcium release channels, and coordinates multi-protein complex formation of the tetrameric skeletal muscle ryanodine receptor. In mouse, deletion of this homologous gene causes congenital heart disorder known as noncompaction of left ventricular myocardium. Multiple alternatively spliced variants, encoding the same protein, have been identified. The human genome contains five pseudogenes related to this gene, at least one of which is transcribed.
  • Alternative Names
  • FKBP1; PKC12; PKCI2; FKBP12; PPIASE; FKBP-12; FKBP-1A; peptidyl-prolyl cis-trans isomerase FKBP1A; 12 kDa FK506-binding protein; 12 kDa FKBP; FK506 binding protein 1A, 12kDa; FK506 binding protein12; FK506-binding protein 1; FK506-binding protein 12; FK506-binding protein 1A; FK506-binding protein, T-cell, 12-kD; FKBP12-Exip3; PPIase FKBP1A; calstabin-1; immunophilin FKBP12; protein kinase C inhibitor 2; rotamase

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