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Magic™ Antibody Discovery - Human FOLR2 (17-228) Membrane Protein, Partial, -His tag (CAT#: MP0117F)

Datasheet
This membrane protein is Human FOLR2 (17-228). It has been tested in SDS-PAGE, ELISA. We provide this protein to facilitate your membrane protein antibody discovery and development.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • FOLR2
  • Protein Length
  • ECD
  • Molecular Weight
  • The protein has a calculated MW of 26.5 kDa. The protein migrates as 30-35 kDa under reducing (R) condition (SDS-PAGE) due to N-linked glycosylation which has been verified by PNGase F digestion.
  • Sequence
  • AA Thr 17 - His 228 (Accession # P14207-1).

Product Description

  • Activity
  • Yes
  • Application
  • SDS-PAGE, ELISA
  • Expression Systems
  • HEK293
  • Tag
  • His tag at the C-terminus
  • Protein Format
  • Soluble
  • Reconstitution
  • Please see Certificate of Analysis for specific instructions.
  • Endotoxin
  • <1.0 EU/μg by the LAL method
  • Purity
  • >90% as determined by SDS-PAGE.
  • Buffer
  • Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally trehalose is added as protectant before lyophilization.

Target

  • Target Protein
  • FOLR2
  • Full Name
  • folate receptor beta
  • Introduction
  • The protein encoded by this gene is a member of the folate receptor (FOLR) family, and these genes exist in a cluster on chromosome 11. Members of this gene family have a high affinity for folic acid and for several reduced folic acid derivatives, and they mediate delivery of 5-methyltetrahydrofolate to the interior of cells. This protein has a 68% and 79% sequence homology with the FOLR1 and FOLR3 proteins, respectively. Although this protein was originally thought to be specific to placenta, it can also exist in other tissues, and it may play a role in the transport of methotrexate in synovial macrophages in rheumatoid arthritis patients. Multiple transcript variants that encode the same protein have been found for this gene.
  • Alternative Names
  • FBP; FOLR1; FR-P3; FRbeta; FR-BETA; BETA-HFR; FBP/PL-1; folate receptor beta; folate receptor 2 (fetal); folate receptor alpha; folate receptor, fetal/placental; folate-binding protein, fetal/placental; placental folate-binding protein

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