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Magic™ Antibody Discovery - Human GITR / TNFRSF18 (26-161) Membrane Protein, Partial, -hIgG1 Fc -Avi tag (CAT#: MP0178F)

Datasheet
This membrane protein is Human GITR / TNFRSF18 (26-161). It has been tested in SDS-PAGE. We provide this protein to facilitate your membrane protein antibody discovery and development.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • GITR / TNFRSF18
  • Protein Length
  • ECD
  • Molecular Weight
  • The protein has a calculated MW of 43.3 kDa. The protein migrates as 45-50 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
  • Sequence
  • AA Gln 26 - Glu 161 (Accession # Q9Y5U5-1).

Product Description

  • Application
  • SDS-PAGE
  • Expression Systems
  • HEK293
  • Tag
  • Human IgG1 Fc tag at the C-terminus, followed by a Avi tag
  • Protein Format
  • Soluble
  • Reconstitution
  • Please see Certificate of Analysis for specific instructions.
  • Endotoxin
  • <1.0 EU/μg by the LAL method
  • Purity
  • >95% as determined by SDS-PAGE.
  • Buffer
  • Lyophilized from 0.22 μm filtered solution in Tris with Glycine, Arginine and NaCl, pH7.5. Normally trehalose is added as protectant before lyophilization.

Target

  • Target Protein
  • GITR / TNFRSF18
  • Full Name
  • TNF receptor superfamily member 18
  • Introduction
  • This gene encodes a member of the TNF-receptor superfamily. The encoded receptor has been shown to have increased expression upon T-cell activation, and it is thought to play a key role in dominant immunological self-tolerance maintained by CD25(+)CD4(+) regulatory T cells. Knockout studies in mice also suggest the role of this receptor is in the regulation of CD3-driven T-cell activation and programmed cell death. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
  • Alternative Names
  • AITR; GITR; CD357; GITR-D; ENERGEN; tumor necrosis factor receptor superfamily member 18; TNF receptor superfamily activation-inducible protein; activation-inducible TNFR family receptor; glucocorticoid-induced TNFR-related protein

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