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Magic™ Antibody Discovery - Human IL-17A / CTLA-8 (24-155) Membrane Protein, Partial (CAT#: MP0302F)

Datasheet
This membrane protein is Human IL-17A / CTLA-8 (24-155). It has been tested in SDS-PAGE, ELISA, Cell based assay, SEC-SEC-MALS, BLI. We provide this protein to facilitate your membrane protein antibody discovery and development.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • IL-17A / CTLA-8
  • Protein Length
  • ECD
  • Molecular Weight
  • The protein has a calculated MW of 15.3 kDa. the protein migrates as 18 kDa under reducing (R) condition, and 28 kDa under non-reducing (NR) condition (SDS-PAGE).
  • Sequence
  • AA Gly 24 - Ala 155 (Accession # Q16552).

Product Description

  • Activity
  • Yes
  • Application
  • SDS-PAGE, ELISA, Cell based assay, SEC-SEC-MALS, BLI
  • Expression Systems
  • E.coli
  • Tag
  • No tag
  • Protein Format
  • Soluble
  • Reconstitution
  • Please see Certificate of Analysis for specific instructions.
  • Endotoxin
  • <1.0 EU/μg by the LAL method
  • Purity
  • >95% as determined by SDS-PAGE.
    >95% as determined by SEC-MALS.
  • Buffer
  • Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally trehalose is added as protectant before lyophilization.

Target

  • Target Protein
  • IL-17A / CTLA-8
  • Full Name
  • interleukin 17A
  • Introduction
  • This gene is a member of the IL-17 receptor family which includes five members (IL-17RA-E) and the encoded protein is a proinflammatory cytokine produced by activated T cells. IL-17A-mediated downstream pathways induce the production of inflammatory molecules, chemokines, antimicrobial peptides, and remodeling proteins. The encoded protein elicits crucial impacts on host defense, cell trafficking, immune modulation, and tissue repair, with a key role in the induction of innate immune defenses. This cytokine stimulates non-hematopoietic cells and promotes chemokine production thereby attracting myeloid cells to inflammatory sites. This cytokine also regulates the activities of NF-kappaB and mitogen-activated protein kinases and can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). IL-17A plays a pivotal role in various infectious diseases, inflammatory and autoimmune disorders, and cancer. High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis. The lung damage induced by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is to a large extent, a result of the inflammatory response promoted by cytokines such as IL17A.
  • Alternative Names
  • IL17; CTLA8; IL-17; CTLA-8; IL-17A; interleukin-17A; cytotoxic T-lymphocyte-associated antigen 8; cytotoxic T-lymphocyte-associated protein 8; interleukin 17 (cytotoxic T-lymphocyte-associated serine esterase 8)

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