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Magic™ Antibody Discovery - Human IL-2 R alpha / CD25 (22-213) Membrane Protein, Partial, -hIgG1 Fc tag (CAT#: MPX4716K)

Datasheet
This membrane protein is Human IL2RA. We provide this protein to facilitate your membrane protein antibody discovery and development.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • IL2RA
  • Protein Length
  • ECD
  • Protein Class
  • Receptor
  • Molecular Weight
  • 48.4 kDa
  • TMD
  • 1
  • Sequence
  • AA Glu 22 - Cys 213 (Accession # NP_000408)

Product Description

  • Activity
  • Yes
  • Expression Systems
  • HEK293
  • Tag
  • Human IgG1 Fc tag at the C-terminus
  • Protein Format
  • Soluble
  • Reconstitution
  • Please see Certificate of Analysis for specific instructions.
  • Endotoxin
  • <1.0 EU per μg by the LAL method
  • Purity
  • >95% as determined by SDS-PAGE.
    >90% as determined by SEC-MALS.
  • Buffer
  • Lyophilized from 0.22 μm filtered solution in Tris with Glycine, Arginine and NaCl, pH7.5.

Target

  • Target Protein
  • IL2RA
  • Full Name
  • Interleukin 2 receptor subunit alpha
  • Introduction
  • The interleukin 2 (IL2) receptor alpha (IL2RA) and beta (IL2RB) chains, together with the common gamma chain (IL2RG), constitute the high-affinity IL2 receptor. Homodimeric alpha chains (IL2RA) result in low-affinity receptor, while homodimeric beta (IL2RB) chains produce a medium-affinity receptor. Normally an integral-membrane protein, soluble IL2RA has been isolated and determined to result from extracellular proteolyisis. Alternately-spliced IL2RA mRNAs have been isolated, but the significance of each is presently unknown. Mutations in this gene are associated with interleukin 2 receptor alpha deficiency. Patients with severe Coronavirus Disease 2019 (COVID-19), the disease caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), have significantly elevated levels of IL2R in their plasma. Similarly, serum IL-2R levels are found to be elevated in patients with different types of carcinomas. Certain IL2RA and IL2RB gene polymorphisms have been associated with lung cancer risk.
  • Alternative Names
  • IL2RA; p55; CD25; IL2R; IMD41; TCGFR; IDDM10; IL-2 receptor subunit alpha; IL-2R subunit alpha; TAC antigen; interleukin 2 receptor, alpha; Interleukin 2 receptor subunit alpha

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