Close
Close

Magic™ Antibody Discovery - Human IL-21 (20-236) Membrane Protein, Partial, -hIgG1 Fc tag (CAT#: MP0377F)

Datasheet
This membrane protein is Human IL-21R (20-236). It has been tested in SDS-PAGE, ELISA. We provide this protein to facilitate your membrane protein antibody discovery and development.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • IL-21R
  • Protein Length
  • ECD
  • Molecular Weight
  • The protein has a calculated MW of 51.6 kDa. As a result of glycosylation, the protein migrates as 60-70 kDa under reducing (R) condition, and 120-130 kDa under non-reducing (NR) condition (SDS-PAGE).
  • Sequence
  • AA Cys 20 - Pro 236 (Accession # AAH04348).

Product Description

  • Activity
  • Yes
  • Application
  • SDS-PAGE, ELISA
  • Expression Systems
  • HEK293
  • Tag
  • Human IgG1 Fc tag at the C-terminus
  • Protein Format
  • Soluble
  • Reconstitution
  • Please see Certificate of Analysis for specific instructions.
  • Endotoxin
  • <1.0 EU/μg by the LAL method
  • Purity
  • >92% as determined by SDS-PAGE.
  • Buffer
  • Lyophilized from 0.22 μm filtered solution in 50 mM Tris, 100 mM Glycine, pH7.5. Normally trehalose is added as protectant before lyophilization.

Target

  • Target Protein
  • IL-21R
  • Full Name
  • interleukin 21 receptor
  • Introduction
  • The protein encoded by this gene is a cytokine receptor for interleukin 21 (IL21). It belongs to the type I cytokine receptors, and has been shown to form a heterodimeric receptor complex with the common gamma-chain, a receptor subunit also shared by the receptors for interleukin 2, 4, 7, 9, and 15. This receptor transduces the growth promoting signal of IL21, and is important for the proliferation and differentiation of T cells, B cells, and natural killer (NK) cells. The ligand binding of this receptor leads to the activation of multiple downstream signaling molecules, including JAK1, JAK3, STAT1, and STAT3. Knockout studies of a similar gene in mouse suggest a role for this gene in regulating immunoglobulin production. Three alternatively spliced transcript variants have been described.
  • Alternative Names
  • NILR; CD360; IMD56; interleukin-21 receptor; IL-21 receptor; novel interleukin receptor

Customer reviews and Q&As    

Related Products
Online Inquiry
CONTACT US
USA:
Europe:
Germany:
Call us at:
USA:
UK:
Germany:
Fax:
Email:
Our customer service representatives are available 24 hours a day, 7 days a week. Contact Us
© 2024 Creative Biolabs. | Contact Us