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Magic™ Antibody Discovery - Human IL-3 R alpha / CD123 (19-305) Membrane Protein, Partial, -Llama IgG2b Fc tag, low endotoxin (CAT#: MP0367F)

Datasheet
This membrane protein is Human IL-3 R alpha / CD123 (19-305). It has been tested in SDS-PAGE. We provide this protein to facilitate your membrane protein antibody discovery and development.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • IL-3 R alpha / CD123
  • Protein Length
  • ECD
  • Molecular Weight
  • The protein has a calculated MW of 60.9 kDa. The protein migrates as 45 kDa, 55 kDa and 80 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
  • Sequence
  • AA Thr 19 - Arg 305 (Accession # P26951-1).

Product Description

  • Application
  • SDS-PAGE
  • Expression Systems
  • HEK293
  • Tag
  • Llama IgG2b Fc tag at the C-terminus
  • Protein Format
  • Soluble
  • Reconstitution
  • Please see Certificate of Analysis for specific instructions.
  • Endotoxin
  • <0.01 EU/μg by the LAL method
  • Purity
  • >90% as determined by SDS-PAGE.
  • Buffer
  • Lyophilized from 0.22 μm filtered solution in Tris with Glycine, Arginine and NaCl, pH7.5. Normally trehalose is added as protectant before lyophilization.

Target

  • Target Protein
  • IL-3 R alpha / CD123
  • Full Name
  • interleukin 3 receptor subunit alpha
  • Introduction
  • The protein encoded by this gene is an interleukin 3 specific subunit of a heterodimeric cytokine receptor. The receptor is comprised of a ligand specific alpha subunit and a signal transducing beta subunit shared by the receptors for interleukin 3 (IL3), colony stimulating factor 2 (CSF2/GM-CSF), and interleukin 5 (IL5). The binding of this protein to IL3 depends on the beta subunit. The beta subunit is activated by the ligand binding, and is required for the biological activities of IL3. This gene and the gene encoding the colony stimulating factor 2 receptor alpha chain (CSF2RA) form a cytokine receptor gene cluster in a X-Y pseudoautosomal region on chromosomes X or Y. Alternatively spliced transcript variants encoding distinct isoforms have been found.
  • Alternative Names
  • IL3R; CD123; IL3RX; IL3RY; IL3RAY; hIL-3Ra; interleukin-3 receptor subunit alpha; CD123 antigen; IL-3 receptor subunit alpha; IL-3R subunit alpha; IL-3R-alpha; IL-3RA; interleukin 3 receptor, alpha (low affinity)

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