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Magic™ Antibody Discovery - Human Integrin alpha M beta 2 (ITGAM&ITGB2) Heterodimer (17-1105(ITGAM)&23-700(ITGB2)) Membrane Protein, Partial, -His Tag & Tag free (CAT#: MP0321F)

Datasheet
This membrane protein is Human Integrin alpha M beta 2 (ITGAM&ITGB2) Heterodimer (17-1105(ITGAM)&23-700(ITGB2)). It has been tested in SDS-PAGE. We provide this protein to facilitate your membrane protein antibody discovery and development.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • Integrin alpha M beta 2 (ITGAM&ITGB2) Heterodimer
  • Protein Length
  • ECD
  • Molecular Weight
  • Calculated MW of 127.2 kDa (ITGAM) and 80.2 kDa (ITGB2). The non-reducing (NR) protein migrates as 150-180 kDa (ITGAM) and 85-95 kDa (ITGB2) respectively due to glycosylation.
  • Sequence
  • AA Phe 17 - Asn 1105 (ITGAM) & Gln 23 - Asn 700 (ITGB2) (Accession # P11215-2 (ITGAM) & P05107-1 (ITGB2)).

Product Description

  • Application
  • SDS-PAGE
  • Expression Systems
  • HEK293
  • Tag
  • ITGAM is fused with an acidic tail at the C-terminus. and followed by His tag and subunit ITGB2 contains no tag but a basic tail at the C-terminus.
  • Protein Format
  • Soluble
  • Reconstitution
  • Please see Certificate of Analysis for specific instructions.
  • Endotoxin
  • <1.0 EU/μg by the LAL method
  • Purity
  • >95% as determined by SDS-PAGE.
  • Buffer
  • Lyophilized from 0.22 μm filtered solution in 50 mM Tris, 150 mM NaCl, pH7.5. Normally trehalose is added as protectant before lyophilizatio

Target

  • Target Protein
  • Integrin alpha M beta 2 (ITGAM&ITGB2) Heterodimer
  • Full Name
  • integrin subunit alpha V&integrin subunit beta 5
  • Introduction
  • The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha subunit and a beta subunit that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha V subunit. This subunit associates with beta 1, beta 3, beta 5, beta 6 and beta 8 subunits. The heterodimer consisting of alpha V and beta 3 subunits is also known as the vitronectin receptor. This integrin may regulate angiogenesis and cancer progression. Alternative splicing results in multiple transcript variants. Note that the integrin alpha 5 and integrin alpha V subunits are encoded by distinct genes. & This gene encodes a beta subunit of integrin, which can combine with different alpha chains to form a variety of integrin heterodimers. Integrins are integral cell-surface receptors that participate in cell adhesion as well as cell-surface mediated signaling. The alphav beta5 integrin is involved in adhesion to vitronectin.
  • Alternative Names
  • ITGAV, integrin, alpha V, antigen identified by monoclonal L230 , integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51) , MSK8, vitronectin receptor , VNRA, VTNR, integrin alpha-V, CD51, integrin alphaVbeta3, vitronectin receptor subunit alpha, antigen identified by monoclonal L230, integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51), MSK8, VNRA, VTNR, DKFZp686A08142,

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