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Magic™ Antibody Discovery - Human Integrin alpha V beta 8 (31-992(ITGAV)&43-684(ITGB8)) Membrane Protein, Partial, -His -Avi tag & Tag free, [Biotin] (CAT#: MP0231F)

Datasheet
This membrane protein is Human Integrin alpha V beta 8 (31-992(ITGAV)&43-684(ITGB8)). It has been tested in SDS-PAGE, ELISA. We provide this protein to facilitate your membrane protein antibody discovery and development.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • Integrin alpha V beta 8
  • Protein Length
  • ECD
  • Molecular Weight
  • Calculated MW of 114.7 kDa (ITGAV) and 76.5 kDa (ITGB8). The non-reducing (NR) protein migrates as 145-170 kDa (ITGAV) and 88-95 kDa (ITGB8) respectively due to glycosylation.
  • Sequence
  • AA Phe 31 - Val 992 (ITGAV) & Glu 43 - Arg 684 (ITGB8) (Accession # NP_002201.1 (ITGAV) & NP_002205.1 (ITGB8)).

Product Description

  • Activity
  • Yes
  • Application
  • SDS-PAGE, ELISA
  • Expression Systems
  • HEK293
  • Tag
  • Subunit ITGAV is fused with an acidic tail at the C-terminus and followed by a His tag and an Avi tag and subunit ITGB8 contains no tag but a basic tail at the C-terminus.
  • Protein Format
  • Soluble
  • Reconstitution
  • Please see Certificate of Analysis for specific instructions.
  • Endotoxin
  • <1.0 EU/μg by the LAL method
  • Conjugation
  • Biotin
  • Purity
  • >90% as determined by SDS-PAGE.
  • Buffer
  • Lyophilized from 0.22 μm filtered solution in 50 mM Tris, 150 mM NaCl, pH8.0. Normally trehalose is added as protectant before lyophilization.

Target

  • Target Protein
  • Integrin alpha V beta 8
  • Full Name
  • integrin subunit alpha V&integrin subunit beta 8
  • Introduction
  • The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha subunit and a beta subunit that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha V subunit. This subunit associates with beta 1, beta 3, beta 5, beta 6 and beta 8 subunits. The heterodimer consisting of alpha V and beta 3 subunits is also known as the vitronectin receptor. This integrin may regulate angiogenesis and cancer progression. Alternative splicing results in multiple transcript variants. Note that the integrin alpha 5 and integrin alpha V subunits are encoded by distinct genes.& This gene is a member of the integrin beta chain family and encodes a single-pass type I membrane protein with a VWFA domain and four cysteine-rich repeats. This protein noncovalently binds to an alpha subunit to form a heterodimeric integrin complex. In general, integrin complexes mediate cell-cell and cell-extracellular matrix interactions and this complex plays a role in human airway epithelial proliferation. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized.
  • Alternative Names
  • CD51; MSK8; VNRA; VTNR; integrin alpha-V; antigen identified by monoclonal antibody L230; integrin alphaVbeta3; integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51); vitronectin receptor subunit alpha & integrin beta-8

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