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Magic™ Antibody Discovery - Human Integrin isoform alpha-7X2B beta 1 (34-1038(ITGA7X2B)&21-728(ITGB1)) Membrane Protein, Partial, -His Tag & Tag free (CAT#: MP0325F)

Datasheet
This membrane protein is Human Integrin isoform alpha-7X2B beta 1 (34-1038(ITGA7X2B)&21-728(ITGB1)). It has been tested in SDS-PAGE. We provide this protein to facilitate your membrane protein antibody discovery and development.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • Integrin isoform alpha-7X2B beta 1
  • Protein Length
  • ECD
  • Molecular Weight
  • Calculated MW of 116.5 kDa (ITGA7X2B) and 83.7 kDa (ITGB1).The non-reducing (NR) protein migrates as 130-135 kDa (ITGA7X2B) and 100-125 kDa (ITGB1) respectively due to glycosylation.
  • Sequence
  • AA Phe 34 - Trp 1038 (ITGA7X2B) & Gln 21 - Asp 728 (ITGB1) (Accession # Q13683-7 (ITGA7X2B) & P05556-1 (ITGB1)).

Product Description

  • Application
  • SDS-PAGE
  • Expression Systems
  • HEK293
  • Tag
  • ITGA7X2B is fused with an acidic tail at the C-terminus. and followed by His tag and subunit ITGB1 contains no tag but a basic tail at the C-terminus.
  • Protein Format
  • Soluble
  • Reconstitution
  • Please see Certificate of Analysis for specific instructions.
  • Endotoxin
  • <1.0 EU/μg by the LAL method
  • Purity
  • >90% as determined by SDS-PAGE.
  • Buffer
  • Lyophilized from 0.22 μm filtered solution in 50 mM Tris, 150 mM NaCl, pH7.5. Normally trehalose is added as protectant before lyophilization.

Target

  • Target Protein
  • Integrin isoform alpha-7X2B beta 1
  • Full Name
  • integrin subunit alpha 7&integrin subunit beta 1
  • Introduction
  • The protein encoded by this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. They mediate a wide spectrum of cell-cell and cell-matrix interactions, and thus play a role in cell migration, morphologic development, differentiation, and metastasis. This protein functions as a receptor for the basement membrane protein laminin-1. It is mainly expressed in skeletal and cardiac muscles and may be involved in differentiation and migration processes during myogenesis. Defects in this gene are associated with congenital myopathy. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. & Integrins are heterodimeric proteins made up of alpha and beta subunits. At least 18 alpha and 8 beta subunits have been described in mammals. Integrin family members are membrane receptors involved in cell adhesion and recognition in a variety of processes including embryogenesis, hemostasis, tissue repair, immune response and metastatic diffusion of tumor cells. This gene encodes a beta subunit. Multiple alternatively spliced transcript variants which encode different protein isoforms have been found for this gene.
  • Alternative Names
  • Integrin isoform alpha-7X2B beta 1, ITGA7X2BB1, ITGA7X2B&ITGB1

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