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Magic™ Antibody Discovery - Human LIGHT / TNFSF14 (74-240) Membrane Protein, Partial, hIgG1 Fc tag-, Trimer (CAT#: MP0599F)

Datasheet
This membrane protein is Human LIGHT / TNFSF14 (74-240). It has been tested in SDS-PAGE, ELISA, SEC-SEC-MALS, Cell based assay. We provide this protein to facilitate your membrane protein antibody discovery and development.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • LIGHT / TNFSF14
  • Protein Length
  • ECD
  • Molecular Weight
  • The protein has a calculated MW of 82.6 kDa. The protein migrates as 116 kDa under non-reducing (NR) condition (SDS-PAGE) due to glycosylation.
  • Sequence
  • AA Asp 74 - Val 240 (Accession # O43557-1) .

Product Description

  • Activity
  • Yes
  • Application
  • SDS-PAGE, ELISA, SEC-SEC-MALS, Cell based assay
  • Expression Systems
  • HEK293
  • Tag
  • Human IgG1 Fc tag at the N-terminus
  • Protein Format
  • Soluble
  • Reconstitution
  • Please see Certificate of Analysis for specific instructions.
  • Endotoxin
  • <1.0 EU/μg by the LAL method
  • Purity
  • >90% as determined by SDS-PAGE.
    >90% as determined by SEC-MALS.
  • Buffer
  • Lyophilized from 0.22 μm filtered solution in 50 mM Tris, 100 mM Glycine, 150 mM NaCl, pH7.5. Normally trehalose is added as protectant before lyophilization.

Target

  • Target Protein
  • LIGHT / TNFSF14
  • Full Name
  • TNF superfamily member 14
  • Introduction
  • The protein encoded by this gene is a member of the tumor necrosis factor (TNF) ligand family. This protein is a ligand for TNFRSF14, which is a member of the tumor necrosis factor receptor superfamily, and which is also known as a herpesvirus entry mediator (HVEM). This protein may function as a costimulatory factor for the activation of lymphoid cells and as a deterrent to infection by herpesvirus. This protein has been shown to stimulate the proliferation of T cells, and trigger apoptosis of various tumor cells. This protein is also reported to prevent tumor necrosis factor alpha mediated apoptosis in primary hepatocyte. Two alternatively spliced transcript variant encoding distinct isoforms have been reported.
  • Alternative Names
  • LTg; CD258; HVEML; LIGHT; tumor necrosis factor ligand superfamily member 14; herpesvirus entry mediator ligand; tumor necrosis factor (ligand) superfamily, member 14; tumor necrosis factor ligand 1D; tumor necrosis factor superfamily member 14

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