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Magic™ Antibody Discovery - Human LSECtin / CLEC4G (55-293) Membrane Protein, Partial, hIgG1 Fc- tag (CAT#: MP0627F)

Datasheet
This membrane protein is Human LSECtin / CLEC4G (55-293). It has been tested in SDS-PAGE. We provide this protein to facilitate your membrane protein antibody discovery and development.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • LSECtin / CLEC4G
  • Protein Length
  • ECD
  • Molecular Weight
  • The protein has a calculated MW of 52.1 kDa. The protein migrates as 58-66 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
  • Sequence
  • AA Lys 55 - Cys 293 (Accession # Q6UXB4-1).

Product Description

  • Application
  • SDS-PAGE
  • Expression Systems
  • HEK293
  • Tag
  • Human IgG1 Fc tag at the N-terminus
  • Protein Format
  • Soluble
  • Reconstitution
  • Please see Certificate of Analysis for specific instructions.
  • Endotoxin
  • <1.0 EU/μg by the LAL method
  • Purity
  • >85% as determined by SDS-PAGE.
  • Buffer
  • Lyophilized from 0.22 μm filtered solution in 50 mM Tris, 100 mM Glycine, pH7.5. Normally trehalose is added as protectant before lyophilization.

Target

  • Target Protein
  • LSECtin / CLEC4G
  • Full Name
  • C-type lectin domain family 4 member G
  • Introduction
  • This gene encodes a glycan-binding receptor and member of the C-type lectin family which plays a role in the immune response. C-type lectin receptors are pattern recognition receptors located on immune cells that play a role in the recognition and uptake of both self and non-self glycoproteins as well as mediating cell adhesion, glycoprotein clearance, and cell signaling functions. This gene's protein binds complex-type N-glycans of the viral envelope proteins of Ebola virus, West Nile filovirus, and SARS coronavirus, but not HIV or hepatitis C virus. In mouse, this protein has been shown to recognize activated T-cells and to negatively regulate T-cell receptor-mediated signalling. It also acts as a novel, liver-specific regulator of NK cell-mediated immunity in mouse. Multiple transcript variants encoding different isoforms have been found for this gene.
  • Alternative Names
  • LP2698; UNQ431; DTTR431; LSECtin; C-type lectin domain family 4 member G; C-type lectin superfamily 4, member G; liver and lymph node sinusoidal endothelial cell C-type lectin

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