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Magic™ Antibody Discovery - Human MUC-17 (4131-4390) Membrane Protein, Partial, -His tag (CAT#: MP0645F)

Datasheet
This membrane protein is Human MUC-17 (4131-4390). It has been tested in SDS-PAGE. We provide this protein to facilitate your membrane protein antibody discovery and development.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • MUC-17
  • Protein Length
  • ECD
  • Molecular Weight
  • This protein was cleaved within the SEA domain between 4243 Gly and 4244 Ser, and was cleaved into N and C-terminal fragment with calculated MW of 12.6 kDa and 18.6 kDa respectively. The protein migrates as 20 kDa and 25-35 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
  • Sequence
  • AA Arg 4131 - Leu 4390 (Accession # Q685J3-1).

Product Description

  • Application
  • SDS-PAGE
  • Expression Systems
  • HEK293
  • Tag
  • His tag at the C-terminus
  • Protein Format
  • Soluble
  • Reconstitution
  • Please see Certificate of Analysis for specific instructions.
  • Endotoxin
  • <1.0 EU/μg by the LAL method
  • Purity
  • >90% as determined by SDS-PAGE.
  • Buffer
  • Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally trehalose is added as protectant before lyophilization

Target

  • Target Protein
  • MUC-17
  • Full Name
  • mucin 17, cell surface associated
  • Introduction
  • The protein encoded by this gene is a membrane-bound mucin that provides protection to gut epithelial cells. The encoded protein contains about 60 tandem repeats, with each repeat being around 60 aa. N-glycosylation enables the encoded protein to localize on the cell surface, while the C-terminus interacts with the scaffold protein PDZ domain containing 1 (PDZK1). Two transcript variants, one protein-coding and the other non-protein coding, have been found for this gene.
  • Alternative Names
  • MUC3; MUC-3; MUC-17; mucin-17; membrane mucin MUC17; secreted mucin MUC17; small intestinal mucin MUC3; small intestinal mucin-3

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